De Clerck F - Search Results

1

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs.

Valentin JP, Hoffmann P, De Clerck F, Hammond TG, Hondeghem L. Valentin JP, et al. Among authors: de clerck f. J Pharmacol Toxicol Methods. 2004 May-Jun;49(3):171-81. doi: 10.1016/j.vascn.2004.03.008. J Pharmacol Toxicol Methods. 2004. PMID: 15172013 Review.

2

Detection of proarrhythmia in the female rabbit heart: blinded validation.

Hondeghem LM, Lu HR, van Rossem K, De Clerck F. Hondeghem LM, et al. Among authors: de clerck f. J Cardiovasc Electrophysiol. 2003 Mar;14(3):287-94. doi: 10.1046/j.1540-8167.2003.02466.x. J Cardiovasc Electrophysiol. 2003. PMID: 12716112

3

Drug-induced QTC prolongation dangerously underestimates proarrhythmic potential: lessons from terfenadine.

Hondeghem LM, Dujardin K, Hoffmann P, Dumotier B, De Clerck F. Hondeghem LM, et al. Among authors: de clerck f. J Cardiovasc Pharmacol. 2011 May;57(5):589-97. doi: 10.1097/FJC.0b013e3182135e91. J Cardiovasc Pharmacol. 2011. PMID: 21346598

4

Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia.

Hondeghem LM, Dujardin K, De Clerck F. Hondeghem LM, et al. Among authors: de clerck f. Cardiovasc Res. 2001 May;50(2):345-53. doi: 10.1016/s0008-6363(01)00259-0. Cardiovasc Res. 2001. PMID: 11334838

5

Preclinical cardiovascular safety evaluations of biologics: optimizing the approach and follow-up.

Hondeghem L, De Clerck F. Hondeghem L, et al. Among authors: de clerck f. BioDrugs. 2012 Oct 1;26(5):275-82. doi: 10.2165/11633490-000000000-00000. BioDrugs. 2012. PMID: 22909102

6

Short patent lives jeopardize drug and patient safety.

Hondeghem LM, De Clerck F, Camm J. Hondeghem LM, et al. Among authors: de clerck f. J Cardiovasc Pharmacol. 2007 Oct;50(4):353-7. doi: 10.1097/FJC.0b013e3181514032. J Cardiovasc Pharmacol. 2007. PMID: 18049301

7

QT and JT dispersion in the drug-induced long QT syndrome in anaesthetized rabbits is accurately detected by a three-lead surface ECG measurement.

Lu HR, Van Ammel K, Vlaminckx E, De Clerck F. Lu HR, et al. Among authors: de clerck f. J Pharmacol Toxicol Methods. 2004 Mar-Apr;49(2):71-9. doi: 10.1016/j.vascn.2003.10.003. J Pharmacol Toxicol Methods. 2004. PMID: 14990331

8

Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations.

Lu HR, Vlaminckx E, Van Ammel K, De Clerck F. Lu HR, et al. Among authors: de clerck f. Eur J Pharmacol. 2002 Oct 4;452(2):183-92. doi: 10.1016/s0014-2999(02)02246-x. Eur J Pharmacol. 2002. PMID: 12354568

9

Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model.

Lu HR, Remeysen P, Somers K, Saels A, De Clerck F. Lu HR, et al. Among authors: de clerck f. J Cardiovasc Electrophysiol. 2001 May;12(5):538-45. doi: 10.1046/j.1540-8167.2001.00538.x. J Cardiovasc Electrophysiol. 2001. PMID: 11386514

10

Are there sex-specific differences in ventricular repolarization or in drug-induced early afterdepolarizations in isolated rabbit purkinje fibers?

Lu HR, Mariën R, Saels A, De Clerck F. Lu HR, et al. Among authors: de clerck f. J Cardiovasc Pharmacol. 2000 Jul;36(1):132-9. doi: 10.1097/00005344-200007000-00018. J Cardiovasc Pharmacol. 2000. PMID: 10892671

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