Demarest KT - Search Results

1

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.

Zhang HC, Ye H, Conway BR, Derian CK, Addo MF, Kuo GH, Hecker LR, Croll DR, Li J, Westover L, Xu JZ, Look R, Demarest KT, Andrade-Gordon P, Damiano BP, Maryanoff BE. Zhang HC, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3245-50. doi: 10.1016/j.bmcl.2004.03.090. Bioorg Med Chem Lett. 2004. PMID: 15149684

2

Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin.

Matthews JM, Liotta F, Hageman W, Rivero RA, Westover L, Yang M, Xu J, Demarest K. Matthews JM, et al. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1155-9. doi: 10.1016/j.bmcl.2003.12.071. Bioorg Med Chem Lett. 2004. PMID: 14980655

3

Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.

Zhang R, Wang A, DeAngelis A, Pelton P, Xu J, Zhu P, Zhou L, Demarest K, Murray WV, Kuo GH. Zhang R, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3855-9. doi: 10.1016/j.bmcl.2007.05.007. Epub 2007 May 10. Bioorg Med Chem Lett. 2007. PMID: 17524639

4

Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity.

Dyatkin AB, Hoekstra WJ, Hlasta DJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Gunnet JW, Hageman W, Look R, Maryanoff BE. Dyatkin AB, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3081-4. doi: 10.1016/s0960-894x(02)00649-2. Bioorg Med Chem Lett. 2002. PMID: 12372506

5

Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists.

Matthews JM, Greco MN, Hecker LR, Hoekstra WJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Maryanoff BE. Matthews JM, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2003 Feb 24;13(4):753-6. doi: 10.1016/s0960-894x(02)01059-4. Bioorg Med Chem Lett. 2003. PMID: 12639574

6

Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

Zhang HC, White KB, Ye H, McComsey DF, Derian CK, Addo MF, Andrade-Gordon P, Eckardt AJ, Conway BR, Westover L, Xu JZ, Look R, Demarest KT, Emanuel S, Maryanoff BE. Zhang HC, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3049-53. doi: 10.1016/s0960-894x(03)00644-9. Bioorg Med Chem Lett. 2003. PMID: 12941331

7

Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.

Kuo GH, Prouty C, DeAngelis A, Shen L, O'Neill DJ, Shah C, Connolly PJ, Murray WV, Conway BR, Cheung P, Westover L, Xu JZ, Look RA, Demarest KT, Emanuel S, Middleton SA, Jolliffe L, Beavers MP, Chen X. Kuo GH, et al. Among authors: demarest kt. J Med Chem. 2003 Sep 11;46(19):4021-31. doi: 10.1021/jm030115o. J Med Chem. 2003. PMID: 12954055

8

Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3 beta (GSK-3 beta) inhibitors.

Shen L, Prouty C, Conway BR, Westover L, Xu JZ, Look RA, Chen X, Beavers MP, Roberts J, Murray WV, Demarest KT, Kuo GH. Shen L, et al. Among authors: demarest kt. Bioorg Med Chem. 2004 Mar 1;12(5):1239-55. doi: 10.1016/j.bmc.2003.09.047. Bioorg Med Chem. 2004. PMID: 14980636

9

Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates.

Matthews JM, Hoekstra WJ, Dyatkin AB, Hecker LR, Hlasta DJ, Poulter BL, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Reynolds CH, Maryanoff BE. Matthews JM, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2747-52. doi: 10.1016/j.bmcl.2004.03.083. Bioorg Med Chem Lett. 2004. PMID: 15125926

10

Design, synthesis, and biological evaluation of novel 7-azaindolyl-heteroaryl-maleimides as potent and selective glycogen synthase kinase-3beta (GSK-3beta) inhibitors.

O'Neill DJ, Shen L, Prouty C, Conway BR, Westover L, Xu JZ, Zhang HC, Maryanoff BE, Murray WV, Demarest KT, Kuo GH. O'Neill DJ, et al. Among authors: demarest kt. Bioorg Med Chem. 2004 Jun 15;12(12):3167-85. doi: 10.1016/j.bmc.2004.04.010. Bioorg Med Chem. 2004. PMID: 15158785

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