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66 results

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Page 1
A novel series of potent and selective small molecule inhibitors of the complement component C1s.
Subasinghe NL, Ali F, Illig CR, Jonathan Rudolph M, Klein S, Khalil E, Soll RM, Bone RF, Spurlino JC, DesJarlais RL, Crysler CS, Cummings MD, Morris PE Jr, Kilpatrick JM, Sudhakara Babu Y. Subasinghe NL, et al. Among authors: desjarlais rl. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3043-7. doi: 10.1016/j.bmcl.2004.04.034. Bioorg Med Chem Lett. 2004. PMID: 15149641
Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.
Wilson KJ, Illig CR, Subasinghe N, Hoffman JB, Rudolph MJ, Soll R, Molloy CJ, Bone R, Green D, Randall T, Zhang M, Lewandowski FA, Zhou Z, Sharp C, Maguire D, Grasberger B, DesJarlais RL, Spurlino J. Wilson KJ, et al. Among authors: desjarlais rl. Bioorg Med Chem Lett. 2001 Apr 9;11(7):915-8. doi: 10.1016/s0960-894x(01)00102-0. Bioorg Med Chem Lett. 2001. PMID: 11294390
Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.
Subasinghe NL, Illig C, Hoffman J, Rudolph MJ, Wilson KJ, Soll R, Randle T, Green D, Lewandowski F, Zhang M, Bone R, Spurlino J, DesJarlais R, Deckman I, Molloy CJ, Manthey C, Zhou Z, Sharp C, Maguire D, Crysler C, Grasberger B. Subasinghe NL, et al. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1379-82. doi: 10.1016/s0960-894x(01)00247-5. Bioorg Med Chem Lett. 2001. PMID: 11378359
Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.
Rudolph MJ, Illig CR, Subasinghe NL, Wilson KJ, Hoffman JB, Randle T, Green D, Molloy CJ, Soll RM, Lewandowski F, Zhang M, Bone R, Spurlino JC, Deckman IC, Manthey C, Sharp C, Maguire D, Grasberger BL, DesJarlais RL, Zhou Z. Rudolph MJ, et al. Among authors: desjarlais rl. Bioorg Med Chem Lett. 2002 Feb 11;12(3):491-5. doi: 10.1016/s0960-894x(01)00787-9. Bioorg Med Chem Lett. 2002. PMID: 11814826
Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK).
Cywin CL, Zhao BP, McNeil DW, Hrapchak M, Prokopowicz AS, Goldberg DR, Morwick TM, Gao A, Jakes S, Kashem M, Magolda RL, Soll RM, Player MR, Bobko MA, Rinker J, DesJarlais RL, Winters MP. Cywin CL, et al. Among authors: desjarlais rl. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1415-8. doi: 10.1016/s0960-894x(03)00163-x. Bioorg Med Chem Lett. 2003. PMID: 12668002
Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.
Carver TE, Bordeau B, Cummings MD, Petrella EC, Pucci MJ, Zawadzke LE, Dougherty BA, Tredup JA, Bryson JW, Yanchunas J Jr, Doyle ML, Witmer MR, Nelen MI, DesJarlais RL, Jaeger EP, Devine H, Asel ED, Springer BA, Bone R, Salemme FR, Todd MJ. Carver TE, et al. Among authors: desjarlais rl. J Biol Chem. 2005 Mar 25;280(12):11704-12. doi: 10.1074/jbc.M413278200. Epub 2005 Jan 5. J Biol Chem. 2005. PMID: 15634672 Free article.
Docking: successes and challenges.
Mohan V, Gibbs AC, Cummings MD, Jaeger EP, DesJarlais RL. Mohan V, et al. Among authors: desjarlais rl. Curr Pharm Des. 2005;11(3):323-33. doi: 10.2174/1381612053382106. Curr Pharm Des. 2005. PMID: 15723628 Review.
66 results