RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor.
Stein J, Shah R, Steiner DF, Dey A.
Stein J, et al. Among authors: dey a.
Biochem J. 2006 Nov 15;400(1):209-15. doi: 10.1042/BJ20060506.
Biochem J. 2006.
PMID: 16800814
Free PMC article.
We show, following transient knockdown of PC5/6 in these neuroendocrine cells, that generation of the two bioactive forms, CART I (amino acids 42-89/55-102) and CART II (amino acids 49-89/62-102), from pro-CART is impaired due to a lack particularly of the A isoform …
We show, following transient knockdown of PC5/6 in these neuroendocrine cells, that generation of the two bioactive forms, CART I (amino aci …