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Investigating resistance to 5-Azacytidine and Venetoclax in PDX models of MDS/AML.
Bašová P, Minařík L, Magalhaes-Novais SC, Balounová J, Zemanová Z, Aghová T, Špaček M, Jonášová A, Pimková KG, Procházka J, Sedláček R, Stopka T. Bašová P, et al. Among authors: sedlacek r. Front Oncol. 2025 Jan 7;14:1414950. doi: 10.3389/fonc.2024.1414950. eCollection 2024. Front Oncol. 2025. PMID: 39839764 Free PMC article.
Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes.
Vo P, Imai-Leonard DM, Yang B, Briere A, Shao A, Casanova MI, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Braun R, Brown S, Burrill S, Cho SY, Clementson-Mobbs S, D'Souza A, Dickinson M, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Heaney J, Hérault Y, Angelis MH, Hsu CW, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Meziane H, Murray S, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Ryan J, Salazar J, Seavey Z, Seavitt JR, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Udensi U, Wells S, White J, Willett A, Wotton J, Wurst W, Yoshiki A; International Mouse Phenotyping Consortium; Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C, Moshiri A. Vo P, et al. Among authors: sedlacek r. BMC Genomics. 2025 Jan 20;26(1):48. doi: 10.1186/s12864-025-11222-8. BMC Genomics. 2025. PMID: 39833678 Free PMC article.
The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models.
Novak J, Nahacka Z, Oliveira GL, Brisudova P, Dubisova M, Dvorakova S, Miklovicova S, Dalecka M, Puttrich V, Grycova L, Magalhaes-Novais S, Correia CM, Levoux J, Stepanek L, Prochazka J, Svec D, Reguera DP, Lopez-Domenech G, Zobalova R, Sedlacek R, Terp MG, Gammage PA, Lansky Z, Kittler J, Oliveira PJ, Ditzel HJ, Berridge MV, Rodriguez AM, Boukalova S, Rohlena J, Neuzil J. Novak J, et al. Among authors: sedlacek r. Cell Rep. 2025 Jan 9;44(1):115154. doi: 10.1016/j.celrep.2024.115154. Online ahead of print. Cell Rep. 2025. PMID: 39792553 Free article.
TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases.
Ujevic A, Knizkova D, Synackova A, Pribikova M, Trivic T, Dalinskaya A, Drobek A, Niederlova V, Paprckova D, De Guia R, Kasparek P, Prochazka J, Labaj J, Fedosieieva O, Roeck BF, Mihola O, Trachtulec Z, Sedlacek R, Stepanek O, Draber P. Ujevic A, et al. Among authors: sedlacek r. Nat Commun. 2024 Nov 19;15(1):10013. doi: 10.1038/s41467-024-54399-4. Nat Commun. 2024. PMID: 39562788 Free PMC article.
Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy.
Rico-Llanos G, Spoutil F, Blahova E, Koudelka A, Prochazkova M, Czyrek A, Fafilek B, Prochazka J, Gonzalez Lopez M, Krivanek J, Sedlacek R, Krakow D, Nonaka Y, Nakamura Y, Krejci P. Rico-Llanos G, et al. Among authors: sedlacek r. J Bone Miner Res. 2024 Nov 29;39(12):1783-1792. doi: 10.1093/jbmr/zjae173. J Bone Miner Res. 2024. PMID: 39423254 Free PMC article.
Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.
Elrick H, Peterson KA, Willis BJ, Lanza DG, Acar EF, Ryder EJ, Teboul L, Kasparek P, Birling MC, Adams DJ, Bradley A, Braun RE, Brown SD, Caulder A, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Duddy G, Gertsenstein M, Goodwin LO, Hérault Y, Lintott LG, Lloyd KCK, Lorenzo I, Mackenzie M, Mallon AM, McKerlie C, Parkinson H, Ramirez-Solis R, Seavitt JR, Sedlacek R, Skarnes WC, Smedley D, Wells S, White JK, Wood JA; International Mouse Phenotyping Consortium; Murray SA, Heaney JD, Nutter LMJ. Elrick H, et al. Among authors: sedlacek r. Sci Rep. 2024 Sep 30;14(1):22626. doi: 10.1038/s41598-024-72418-8. Sci Rep. 2024. PMID: 39349521 Free PMC article.
DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.
Nedomova M, Haberecht-Müller S, Möller S, Venz S, Prochazkova M, Prochazka J, Sedlak F, Chawengsaksophak K, Hammer E, Kasparek P, Adamek M, Sedlacek R, Konvalinka J, Krüger E, Grantz Saskova K. Nedomova M, et al. Among authors: sedlacek r. iScience. 2024 Sep 5;27(10):110893. doi: 10.1016/j.isci.2024.110893. eCollection 2024 Oct 18. iScience. 2024. PMID: 39328932 Free PMC article.
An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation.
Sinigaglia K, Cherian A, Du Q, Lacovich V, Vukić D, Melicherová J, Linhartova P, Zerad L, Stejskal S, Malik R, Prochazka J, Bondurand N, Sedláček R, O'Connell MA, Keegan LP. Sinigaglia K, et al. Among authors: sedlacek r. Cell Rep. 2024 Aug 27;43(8):114618. doi: 10.1016/j.celrep.2024.114618. Epub 2024 Aug 14. Cell Rep. 2024. PMID: 39146181 Free article.
276 results