Spooren WP - Search Results

1

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.

Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP. Cryan JF, et al. Among authors: spooren wp. J Pharmacol Exp Ther. 2004 Sep;310(3):952-63. doi: 10.1124/jpet.104.066753. Epub 2004 Apr 27. J Pharmacol Exp Ther. 2004. PMID: 15113848

2

Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.

Spooren WP, Vassout A, Neijt HC, Kuhn R, Gasparini F, Roux S, Porsolt RD, Gentsch C. Spooren WP, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1267-75. J Pharmacol Exp Ther. 2000. PMID: 11082464

3

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

Spooren WP, Schoeffter P, Gasparini F, Kuhn R, Gentsch C. Spooren WP, et al. Eur J Pharmacol. 2002 Jan 25;435(2-3):161-70. doi: 10.1016/s0014-2999(01)01562-x. Eur J Pharmacol. 2002. PMID: 11821022

4

Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

Schuler V, Lüscher C, Blanchet C, Klix N, Sansig G, Klebs K, Schmutz M, Heid J, Gentry C, Urban L, Fox A, Spooren W, Jaton AL, Vigouret J, Pozza M, Kelly PH, Mosbacher J, Froestl W, Käslin E, Korn R, Bischoff S, Kaupmann K, van der Putten H, Bettler B. Schuler V, et al. Neuron. 2001 Jul 19;31(1):47-58. doi: 10.1016/s0896-6273(01)00345-2. Neuron. 2001. PMID: 11498050 Free article.

5

Differences in pre- and post-synaptic sensitivity to apomorphine between saline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57BL/6 mice as reflected in climbing activity.

Spooren WP, Vassout A, Waldmeier P, Gentsch C. Spooren WP, et al. Eur J Pharmacol. 1998 Jul 17;353(1):1-4. doi: 10.1016/s0014-2999(98)00382-3. Eur J Pharmacol. 1998. PMID: 9721033

6

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article.

Kuhn R, Pagano A, Stoehr N, Vranesic I, Flor PJ, Lingenhöhl K, Spooren W, Gentsch C, Vassout A, Pilc A, Gasparini F. Kuhn R, et al. Amino Acids. 2002;23(1-3):207-11. doi: 10.1007/s00726-001-0130-6. Amino Acids. 2002. PMID: 12373539 Review.

7

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.

Porter RH, Jaeschke G, Spooren W, Ballard TM, Büttelmann B, Kolczewski S, Peters JU, Prinssen E, Wichmann J, Vieira E, Mühlemann A, Gatti S, Mutel V, Malherbe P. Porter RH, et al. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. doi: 10.1124/jpet.105.089839. Epub 2005 Jul 22. J Pharmacol Exp Ther. 2005. PMID: 16040814

8

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

Walker K, Bowes M, Panesar M, Davis A, Gentry C, Kesingland A, Gasparini F, Spooren W, Stoehr N, Pagano A, Flor PJ, Vranesic I, Lingenhoehl K, Johnson EC, Varney M, Urban L, Kuhn R. Walker K, et al. Neuropharmacology. 2001;40(1):1-9. doi: 10.1016/s0028-3908(00)00113-1. Neuropharmacology. 2001. PMID: 11077065

9

TUNEL-positive cells in the substantia nigra of C57BL/6 mice after a single bolus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Spooren WP, Gentsch C, Wiessner C. Spooren WP, et al. Neuroscience. 1998 Jul;85(2):649-51; discussion 653. doi: 10.1016/s0306-4522(97)00640-4. Neuroscience. 1998. PMID: 9622260 No abstract available.

10

The effect of a subchronic post-lesion treatment with (-)-deprenyl on the sensitivity of 6-OHDA-lesioned rats to apomorphine and d-amphetamine.

Spooren WP, Waldmeier P, Gentsch C. Spooren WP, et al. J Neural Transm (Vienna). 1999;106(9-10):825-33. doi: 10.1007/s007020050203. J Neural Transm (Vienna). 1999. PMID: 10599865

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