Brimacombe JS - Search Results

1

The synthesis of some deoxygenated analogues of early intermediates in the biosynthesis of glycosylphosphatidylinositol (GPI) membrane anchors.

Dix AP, Borissow CN, Ferguson MA, Brimacombe JS. Dix AP, et al. Among authors: brimacombe js. Carbohydr Res. 2004 May 17;339(7):1263-77. doi: 10.1016/j.carres.2004.02.026. Carbohydr Res. 2004. PMID: 15113663

2

Specificities of enzymes of glycosylphosphatidylinositol biosynthesis in Trypanosoma brucei and HeLa cells.

Smith TK, Crossman A, Paterson MJ, Borissow CN, Brimacombe JS, Ferguson MA. Smith TK, et al. Among authors: brimacombe js. J Biol Chem. 2002 Oct 4;277(40):37147-53. doi: 10.1074/jbc.M203371200. Epub 2002 Jul 29. J Biol Chem. 2002. PMID: 12147686 Free article.

3

Substrate specificity of the Plasmodium falciparum glycosylphosphatidylinositol biosynthetic pathway and inhibition by species-specific suicide substrates.

Smith TK, Gerold P, Crossman A, Paterson MJ, Borissow CN, Brimacombe JS, Ferguson MA, Schwarz RT. Smith TK, et al. Among authors: brimacombe js. Biochemistry. 2002 Oct 15;41(41):12395-406. doi: 10.1021/bi020351l. Biochemistry. 2002. PMID: 12369829

4

Further probing of the substrate specificities and inhibition of enzymes involved at an early stage of glycosylphosphatidylinositol (GPI) biosynthesis.

Crossman A Jr, Paterson MJ, Ferguson MA, Smith TK, Brimacombe JS. Crossman A Jr, et al. Among authors: brimacombe js. Carbohydr Res. 2002 Nov 19;337(21-23):2049-59. doi: 10.1016/s0008-6215(02)00187-8. Carbohydr Res. 2002. PMID: 12433470

5

Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness.

Smith TK, Crossman A, Brimacombe JS, Ferguson MA. Smith TK, et al. Among authors: brimacombe js. EMBO J. 2004 Nov 24;23(23):4701-8. doi: 10.1038/sj.emboj.7600456. Epub 2004 Nov 4. EMBO J. 2004. PMID: 15526036 Free PMC article.

6

Parasite and mammalian GPI biosynthetic pathways can be distinguished using synthetic substrate analogues.

Smith TK, Sharma DK, Crossman A, Dix A, Brimacombe JS, Ferguson MA. Smith TK, et al. Among authors: brimacombe js. EMBO J. 1997 Nov 17;16(22):6667-75. doi: 10.1093/emboj/16.22.6667. EMBO J. 1997. PMID: 9362481 Free PMC article.

7

Synthesis of some second-generation substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors.

Crossman A Jr, Brimacombe JS, Ferguson MA, Smith TK. Crossman A Jr, et al. Among authors: brimacombe js. Carbohydr Res. 1999 Sep 15;321(1-2):42-51. doi: 10.1016/s0008-6215(99)00170-6. Carbohydr Res. 1999. PMID: 10612001

8

Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.

Smith TK, Crossman A, Borissow CN, Paterson MJ, Dix A, Brimacombe JS, Ferguson MA. Smith TK, et al. Among authors: brimacombe js. EMBO J. 2001 Jul 2;20(13):3322-32. doi: 10.1093/emboj/20.13.3322. EMBO J. 2001. PMID: 11432820 Free PMC article.

9

An imino-linked carba-disaccharide alpha-D-mannosidase inhibitor.

Cottaz S, Brimacombe JS, Ferguson MA. Cottaz S, et al. Among authors: brimacombe js. Carbohydr Res. 1993 Sep 2;247:341-5. doi: 10.1016/0008-6215(93)84269-c. Carbohydr Res. 1993. PMID: 8221728 No abstract available.

10

Substrate specificity of the dolichol phosphate mannose: glucosaminyl phosphatidylinositol alpha1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes.

Smith TK, Cottaz S, Brimacombe JS, Ferguson MA. Smith TK, et al. Among authors: brimacombe js. J Biol Chem. 1996 Mar 15;271(11):6476-82. doi: 10.1074/jbc.271.11.6476. J Biol Chem. 1996. PMID: 8626449 Free article.

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