Brooks J - Search Results

1

Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.

Eldrup AB, Allerson CR, Bennett CF, Bera S, Bhat B, Bhat N, Bosserman MR, Brooks J, Burlein C, Carroll SS, Cook PD, Getty KL, MacCoss M, McMasters DR, Olsen DB, Prakash TP, Prhavc M, Song Q, Tomassini JE, Xia J. Eldrup AB, et al. Among authors: brooks j. J Med Chem. 2004 Apr 22;47(9):2283-95. doi: 10.1021/jm030424e. J Med Chem. 2004. PMID: 15084127

2

Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.

Eldrup AB, Prhavc M, Brooks J, Bhat B, Prakash TP, Song Q, Bera S, Bhat N, Dande P, Cook PD, Bennett CF, Carroll SS, Ball RG, Bosserman M, Burlein C, Colwell LF, Fay JF, Flores OA, Getty K, LaFemina RL, Leone J, MacCoss M, McMasters DR, Tomassini JE, Von Langen D, Wolanski B, Olsen DB. Eldrup AB, et al. Among authors: brooks j. J Med Chem. 2004 Oct 7;47(21):5284-97. doi: 10.1021/jm040068f. J Med Chem. 2004. PMID: 15456273

3

Synthesis of AZT 5'-triphosphate mimics and their inhibitory effects on HIV-1 reverse transcriptase.

Wang G, Boyle N, Chen F, Rajappan V, Fagan P, Brooks JL, Hurd T, Leeds JM, Rajwanshi VK, Jin Y, Prhavc M, Bruice TW, Cook PD. Wang G, et al. J Med Chem. 2004 Dec 30;47(27):6902-13. doi: 10.1021/jm040116w. J Med Chem. 2004. PMID: 15615539

4

Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase.

Boyle NA, Rajwanshi VK, Prhavc M, Wang G, Fagan P, Chen F, Ewing GJ, Brooks JL, Hurd T, Leeds JM, Bruice TW, Cook PD. Boyle NA, et al. Among authors: brooks jl. J Med Chem. 2005 Apr 7;48(7):2695-700. doi: 10.1021/jm040101y. J Med Chem. 2005. PMID: 15801860

5

2',3'-dideoxynucleoside 5'-beta, gamma-(difluoromethylene) triphosphates with alpha-P-thio or alpha-P-seleno modifications: synthesis and their inhibition of HIV-1 reverse transcriptase.

Boyle NA, Fagan P, Brooks JL, Prhavc M, Lambert J, Cook PD. Boyle NA, et al. Among authors: brooks jl. Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1651-64. doi: 10.1080/15257770500267055. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16438041

6

Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors.

Rajwanshi VK, Prhavc M, Fagan P, Brooks JL, Hurd T, Cook PD, Wang G. Rajwanshi VK, et al. Nucleosides Nucleotides Nucleic Acids. 2005;24(3):179-89. doi: 10.1081/NCN-55707. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 15892257

7

Synthesis of azole nucleoside 5'-monophosphate mimics (P1Ms) and their inhibitory properties of IMP dehydrogenases.

Wang G, Sakthivel K, Rajappan V, Bruice TW, Tucker K, Fagan P, Brooks JL, Hurd T, Leeds JM, Cook PD. Wang G, et al. Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):317-37. doi: 10.1081/ncn-120027838. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15043157

8

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.

Ruebsam F, Murphy DE, Tran CV, Li LS, Zhao J, Dragovich PS, McGuire HM, Xiang AX, Sun Z, Ayida BK, Blazel JK, Kim SH, Zhou Y, Han Q, Kissinger CR, Webber SE, Showalter RE, Shah AM, Tsan M, Patel RA, Thompson PA, Lebrun LA, Hou HJ, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Khandurina J, Brooks J, Okamoto E, Kirkovsky L. Ruebsam F, et al. Among authors: brooks j. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6404-12. doi: 10.1016/j.bmcl.2009.09.045. Epub 2009 Sep 17. Bioorg Med Chem Lett. 2009. PMID: 19818610

9

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.

Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR. Li LS, et al. Among authors: brooks j. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3446-55. doi: 10.1016/j.bmcl.2008.02.072. Epub 2008 Mar 5. Bioorg Med Chem Lett. 2008. PMID: 18457949

10

Socially contagious urination in chimpanzees.

Onishi E, Brooks J, Inoue S, Yamamoto S. Onishi E, et al. Among authors: brooks j. Curr Biol. 2025 Jan 20;35(2):R58-R59. doi: 10.1016/j.cub.2024.11.052. Curr Biol. 2025. PMID: 39837269

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