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Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Shi-Wen X, Chen Y, Denton CP, Eastwood M, Renzoni EA, Bou-Gharios G, Pearson JD, Dashwood M, du Bois RM, Black CM, Leask A, Abraham DJ. Shi-Wen X, et al. Among authors: dashwood m. Mol Biol Cell. 2004 Jun;15(6):2707-19. doi: 10.1091/mbc.e03-12-0902. Epub 2004 Mar 26. Mol Biol Cell. 2004. PMID: 15047866 Free PMC article.
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Shi-Wen X, Rodríguez-Pascual F, Lamas S, Holmes A, Howat S, Pearson JD, Dashwood MR, du Bois RM, Denton CP, Black CM, Abraham DJ, Leask A. Shi-Wen X, et al. Among authors: dashwood mr. Mol Cell Biol. 2006 Jul;26(14):5518-27. doi: 10.1128/MCB.00625-06. Mol Cell Biol. 2006. PMID: 16809784 Free PMC article.
Endothelin-1 stimulates colon cancer adjacent fibroblasts.
Knowles JP, Shi-Wen X, Haque SU, Bhalla A, Dashwood MR, Yang S, Taylor I, Winslet MC, Abraham DJ, Loizidou M. Knowles JP, et al. Among authors: dashwood mr. Int J Cancer. 2012 Mar 15;130(6):1264-72. doi: 10.1002/ijc.26090. Epub 2011 Jun 9. Int J Cancer. 2012. PMID: 21445967
226 results