Negishi M - Search Results

1

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.

Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, LeCluyse EL. Faucette SR, et al. Among authors: negishi m. Drug Metab Dispos. 2004 Mar;32(3):348-58. doi: 10.1124/dmd.32.3.348. Drug Metab Dispos. 2004. PMID: 14977870

2

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.

Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL. Wang H, et al. Among authors: negishi m. J Biol Chem. 2003 Apr 18;278(16):14146-52. doi: 10.1074/jbc.M212482200. Epub 2003 Feb 5. J Biol Chem. 2003. PMID: 12571232 Free article.

3

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.

Wang H, Faucette SR, Gilbert D, Jolley SL, Sueyoshi T, Negishi M, LeCluyse EL. Wang H, et al. Among authors: negishi m. Drug Metab Dispos. 2003 May;31(5):620-30. doi: 10.1124/dmd.31.5.620. Drug Metab Dispos. 2003. PMID: 12695351

4

Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors.

Wang H, Negishi M. Wang H, et al. Among authors: negishi m. Curr Drug Metab. 2003 Dec;4(6):515-25. doi: 10.2174/1389200033489262. Curr Drug Metab. 2003. PMID: 14683479 Review.

5

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.

Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E. Wang H, et al. Among authors: negishi m. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28. J Biol Chem. 2004. PMID: 15123723 Free article.

6

Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells.

Smith CM, Graham RA, Krol WL, Silver IS, Negishi M, Wang H, Lecluyse EL. Smith CM, et al. Among authors: negishi m. J Pharmacol Exp Ther. 2005 Dec;315(3):1256-64. doi: 10.1124/jpet.105.090795. Epub 2005 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 16135700

7

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.

Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H. Faucette SR, et al. Among authors: negishi m. J Pharmacol Exp Ther. 2006 Jun;317(3):1200-9. doi: 10.1124/jpet.105.098160. Epub 2006 Mar 2. J Pharmacol Exp Ther. 2006. PMID: 16513849

8

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.

Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. Faucette SR, et al. Among authors: negishi m. J Pharmacol Exp Ther. 2007 Jan;320(1):72-80. doi: 10.1124/jpet.106.112136. Epub 2006 Oct 13. J Pharmacol Exp Ther. 2007. PMID: 17041008 Free PMC article.

9

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.

Ferguson SS, LeCluyse EL, Negishi M, Goldstein JA. Ferguson SS, et al. Among authors: negishi m. Mol Pharmacol. 2002 Sep;62(3):737-46. doi: 10.1124/mol.62.3.737. Mol Pharmacol. 2002. PMID: 12181452

10

Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.

Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA. Ferguson SS, et al. Among authors: negishi m. Mol Pharmacol. 2005 Sep;68(3):747-57. doi: 10.1124/mol.105.013169. Epub 2005 Jun 2. Mol Pharmacol. 2005. PMID: 15933212

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