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Erlotinib, an effective epidermal growth factor receptor tyrosine kinase inhibitor, induces p27KIP1 up-regulation and nuclear translocation in association with cell growth inhibition and G1/S phase arrest in human non-small-cell lung cancer cell lines.
Ling YH, Li T, Yuan Z, Haigentz M Jr, Weber TK, Perez-Soler R. Ling YH, et al. Among authors: yuan z. Mol Pharmacol. 2007 Aug;72(2):248-58. doi: 10.1124/mol.107.034827. Epub 2007 Apr 24. Mol Pharmacol. 2007. Retraction in: Mol Pharmacol. 2015 Aug;88(2):390. doi: 10.1124/mol.115.08er15a PMID: 17456787 Retracted.
An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.
Yuan Z, Shin J, Wilson A, Goel S, Ling YH, Ahmed N, Dopeso H, Jhawer M, Nasser S, Montagna C, Fordyce K, Augenlicht LH, Aaltonen LA, Arango D, Weber TK, Mariadason JM. Yuan Z, et al. Cancer Res. 2009 Oct 1;69(19):7811-8. doi: 10.1158/0008-5472.CAN-09-0986. Epub 2009 Sep 29. Cancer Res. 2009. PMID: 19789347 Free PMC article.
PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase.
Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, Cuervo AM, Perez-Soler R. Ling YH, et al. Among authors: yuan z. Clin Cancer Res. 2011 Aug 15;17(16):5353-66. doi: 10.1158/1078-0432.CCR-10-1948. Epub 2011 Jun 20. Clin Cancer Res. 2011. Retraction in: Clin Cancer Res. 2013 Sep 1;19(17):4900. doi: 10.1158/1078-0432.CCR-13-1910 PMID: 21690574 Retracted.
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