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Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway.
Piccolo E, Vignati S, Maffucci T, Innominato PF, Riley AM, Potter BV, Pandolfi PP, Broggini M, Iacobelli S, Innocenti P, Falasca M. Piccolo E, et al. Among authors: iacobelli s. Oncogene. 2004 Mar 4;23(9):1754-65. doi: 10.1038/sj.onc.1207296. Oncogene. 2004. PMID: 14755253
Phospholipase Cgamma1 is required for metastasis development and progression.
Sala G, Dituri F, Raimondi C, Previdi S, Maffucci T, Mazzoletti M, Rossi C, Iezzi M, Lattanzio R, Piantelli M, Iacobelli S, Broggini M, Falasca M. Sala G, et al. Among authors: iacobelli s. Cancer Res. 2008 Dec 15;68(24):10187-96. doi: 10.1158/0008-5472.CAN-08-1181. Cancer Res. 2008. PMID: 19074886
An ErbB-3 antibody, MP-RM-1, inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3/Akt signaling.
Sala G, Traini S, D'Egidio M, Vianale G, Rossi C, Piccolo E, Lattanzio R, Piantelli M, Tinari N, Natali PG, Muraro R, Iacobelli S; Consorzio Interuniversitario Nazionale per la Bio-Oncologia. Sala G, et al. Among authors: iacobelli s. Oncogene. 2012 Mar 8;31(10):1275-86. doi: 10.1038/onc.2011.322. Epub 2011 Aug 8. Oncogene. 2012. PMID: 21822299
90K (Mac-2 BP) and galectins in tumor progression and metastasis.
Grassadonia A, Tinari N, Iurisci I, Piccolo E, Cumashi A, Innominato P, D'Egidio M, Natoli C, Piantelli M, Iacobelli S. Grassadonia A, et al. Among authors: iacobelli s. Glycoconj J. 2002;19(7-9):551-6. doi: 10.1023/B:GLYC.0000014085.00706.d4. Glycoconj J. 2002. PMID: 14758079 Review.
Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis.
Rabinovich GA, Cumashi A, Bianco GA, Ciavardelli D, Iurisci I, D'Egidio M, Piccolo E, Tinari N, Nifantiev N, Iacobelli S. Rabinovich GA, et al. Among authors: iacobelli s. Glycobiology. 2006 Mar;16(3):210-20. doi: 10.1093/glycob/cwj056. Epub 2005 Nov 10. Glycobiology. 2006. PMID: 16282605
475 results