Brötz-Oesterhelt H - Search Results

1

New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity.

Beyer D, Kroll HP, Endermann R, Schiffer G, Siegel S, Bauser M, Pohlmann J, Brands M, Ziegelbauer K, Haebich D, Eymann C, Brötz-Oesterhelt H. Beyer D, et al. Antimicrob Agents Chemother. 2004 Feb;48(2):525-32. doi: 10.1128/AAC.48.2.525-532.2004. Antimicrob Agents Chemother. 2004. PMID: 14742205 Free PMC article.

2

New aminoacyl-tRNA synthetase inhibitors as antibacterial agents.

Pohlmann J, Brötz-Oesterhelt H. Pohlmann J, et al. Curr Drug Targets Infect Disord. 2004 Dec;4(4):261-72. doi: 10.2174/1568005043340515. Curr Drug Targets Infect Disord. 2004. PMID: 15578968 Review.

3

Methods to assay inhibitors of tRNA synthetase activity.

Beyer D, Kroll HP, Brötz-Oesterhelt H. Beyer D, et al. Methods Mol Med. 2008;142:53-61. doi: 10.1007/978-1-59745-246-5_5. Methods Mol Med. 2008. PMID: 18437305

4

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.

Brötz-Oesterhelt H, Beyer D, Kroll HP, Endermann R, Ladel C, Schroeder W, Hinzen B, Raddatz S, Paulsen H, Henninger K, Bandow JE, Sahl HG, Labischinski H. Brötz-Oesterhelt H, et al. Nat Med. 2005 Oct;11(10):1082-7. doi: 10.1038/nm1306. Epub 2005 Oct 2. Nat Med. 2005. PMID: 16200071

5

Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.

Brötz-Oesterhelt H, Knezevic I, Bartel S, Lampe T, Warnecke-Eberz U, Ziegelbauer K, Häbich D, Labischinski H. Brötz-Oesterhelt H, et al. J Biol Chem. 2003 Oct 10;278(41):39435-42. doi: 10.1074/jbc.M306479200. Epub 2003 Jul 15. J Biol Chem. 2003. PMID: 12867414 Free article.

6

Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics.

Hinzen B, Raddatz S, Paulsen H, Lampe T, Schumacher A, Häbich D, Hellwig V, Benet-Buchholz J, Endermann R, Labischinski H, Brötz-Oesterhelt H. Hinzen B, et al. ChemMedChem. 2006 Jul;1(7):689-93. doi: 10.1002/cmdc.200600055. ChemMedChem. 2006. PMID: 16902918 No abstract available.

7

Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ.

Sass P, Josten M, Famulla K, Schiffer G, Sahl HG, Hamoen L, Brötz-Oesterhelt H. Sass P, et al. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17474-9. doi: 10.1073/pnas.1110385108. Epub 2011 Oct 3. Proc Natl Acad Sci U S A. 2011. PMID: 21969594 Free PMC article.

8

The impact of transcriptome and proteome analyses on antibiotic drug discovery.

Freiberg C, Brötz-Oesterhelt H, Labischinski H. Freiberg C, et al. Curr Opin Microbiol. 2004 Oct;7(5):451-9. doi: 10.1016/j.mib.2004.08.010. Curr Opin Microbiol. 2004. PMID: 15451499 Review.

9

Functional genomics in antibacterial drug discovery.

Freiberg C, Brötz-Oesterhelt H. Freiberg C, et al. Drug Discov Today. 2005 Jul 1;10(13):927-35. doi: 10.1016/S1359-6446(05)03474-4. Drug Discov Today. 2005. PMID: 15993812 Review.

10

The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes.

Hörömpöli D, Ciglia C, Glüsenkamp KH, Haustedt LO, Falkenstein-Paul H, Bendas G, Berscheid A, Brötz-Oesterhelt H. Hörömpöli D, et al. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e00986-20. doi: 10.1128/AAC.00986-20. Print 2021 Mar 18. Antimicrob Agents Chemother. 2021. PMID: 33468467 Free PMC article.

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