Dunford PJ - Search Results

1

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.

Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. Thurmond RL, et al. Among authors: dunford pj. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. doi: 10.1124/jpet.103.061754. Epub 2004 Jan 13. J Pharmacol Exp Ther. 2004. PMID: 14722321

2

Tricyclic aminopyrimidine histamine H4 receptor antagonists.

Savall BM, Gomez L, Chavez F, Curtis M, Meduna SP, Kearney A, Dunford P, Cowden J, Thurmond RL, Grice C, Edwards JP. Savall BM, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6577-81. doi: 10.1016/j.bmcl.2011.08.014. Epub 2011 Aug 19. Bioorg Med Chem Lett. 2011. PMID: 21920744

3

Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.

Venable JD, Cai H, Chai W, Dvorak CA, Grice CA, Jablonowski JA, Shah CR, Kwok AK, Ly KS, Pio B, Wei J, Desai PJ, Jiang W, Nguyen S, Ling P, Wilson SJ, Dunford PJ, Thurmond RL, Lovenberg TW, Karlsson L, Carruthers NI, Edwards JP. Venable JD, et al. Among authors: dunford pj. J Med Chem. 2005 Dec 29;48(26):8289-98. doi: 10.1021/jm0502081. J Med Chem. 2005. PMID: 16366610

4

The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells.

Dunford PJ, O'Donnell N, Riley JP, Williams KN, Karlsson L, Thurmond RL. Dunford PJ, et al. J Immunol. 2006 Jun 1;176(11):7062-70. doi: 10.4049/jimmunol.176.11.7062. J Immunol. 2006. PMID: 16709868

5

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.

Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL. Dunford PJ, et al. J Allergy Clin Immunol. 2007 Jan;119(1):176-83. doi: 10.1016/j.jaci.2006.08.034. Epub 2006 Oct 13. J Allergy Clin Immunol. 2007. PMID: 17208599

6

The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders.

Zhang M, Thurmond RL, Dunford PJ. Zhang M, et al. Among authors: dunford pj. Pharmacol Ther. 2007 Mar;113(3):594-606. doi: 10.1016/j.pharmthera.2006.11.008. Epub 2006 Dec 28. Pharmacol Ther. 2007. PMID: 17275092 Review.

7

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.

Rao NL, Dunford PJ, Xue X, Jiang X, Lundeen KA, Coles F, Riley JP, Williams KN, Grice CA, Edwards JP, Karlsson L, Fourie AM. Rao NL, et al. Among authors: dunford pj. J Pharmacol Exp Ther. 2007 Jun;321(3):1154-60. doi: 10.1124/jpet.106.115436. Epub 2007 Mar 19. J Pharmacol Exp Ther. 2007. PMID: 17371808

8

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.

Thurmond RL, Gelfand EW, Dunford PJ. Thurmond RL, et al. Among authors: dunford pj. Nat Rev Drug Discov. 2008 Jan;7(1):41-53. doi: 10.1038/nrd2465. Nat Rev Drug Discov. 2008. PMID: 18172439 Review.

9

The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation.

Cowden JM, Zhang M, Dunford PJ, Thurmond RL. Cowden JM, et al. Among authors: dunford pj. J Invest Dermatol. 2010 Apr;130(4):1023-33. doi: 10.1038/jid.2009.358. Epub 2009 Nov 12. J Invest Dermatol. 2010. PMID: 19907432 Free article.

10

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines.

Cowden JM, Riley JP, Ma JY, Thurmond RL, Dunford PJ. Cowden JM, et al. Among authors: dunford pj. Respir Res. 2010 Jun 24;11(1):86. doi: 10.1186/1465-9921-11-86. Respir Res. 2010. PMID: 20573261 Free PMC article.

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