Griffey KI - Search Results

1

(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.

Collado I, Pedregal C, Bueno AB, Marcos A, González R, Blanco-Urgoiti J, Pérez-Castells J, Schoepp DD, Wright RA, Johnson BG, Kingston AE, Moher ED, Hoard DW, Griffey KI, Tizzano JP. Collado I, et al. Among authors: griffey ki. J Med Chem. 2004 Jan 15;47(2):456-66. doi: 10.1021/jm030967o. J Med Chem. 2004. PMID: 14711315

2

Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.

Monn JA, Valli MJ, Johnson BG, Salhoff CR, Wright RA, Howe T, Bond A, Lodge D, Spangle LA, Paschal JW, Campbell JB, Griffey K, Tizzano JP, Schoepp DD. Monn JA, et al. J Med Chem. 1996 Jul 19;39(15):2990-3000. doi: 10.1021/jm9601765. J Med Chem. 1996. PMID: 8709133

3

Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists.

Kingston AE, Griffey K, Johnson MP, Chamberlain MJ, Kelly G, Tomlinson R, Wright RA, Johnson BG, Schoepp DD, Harris JR, Clark BP, Baker RS, Tizzano JT. Kingston AE, et al. Neurosci Lett. 2002 Sep 20;330(2):127-30. doi: 10.1016/s0304-3940(02)00751-6. Neurosci Lett. 2002. PMID: 12231428

4

The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam.

Tizzano JP, Griffey KI, Schoepp DD. Tizzano JP, et al. Among authors: griffey ki. Pharmacol Biochem Behav. 2002 Sep;73(2):367-74. doi: 10.1016/s0091-3057(02)00850-x. Pharmacol Biochem Behav. 2002. PMID: 12117591

5

In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders.

Rorick-Kehn LM, Johnson BG, Knitowski KM, Salhoff CR, Witkin JM, Perry KW, Griffey KI, Tizzano JP, Monn JA, McKinzie DL, Schoepp DD. Rorick-Kehn LM, et al. Among authors: griffey ki. Psychopharmacology (Berl). 2007 Jul;193(1):121-36. doi: 10.1007/s00213-007-0758-3. Epub 2007 Mar 24. Psychopharmacology (Berl). 2007. PMID: 17384937

6

Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice.

Tizzano JP, Griffey KI, Schoepp DD. Tizzano JP, et al. Among authors: griffey ki. Ann N Y Acad Sci. 1995 Sep 15;765:230-5; discussion 248. doi: 10.1111/j.1749-6632.1995.tb16579.x. Ann N Y Acad Sci. 1995. PMID: 7486609 No abstract available.

7

Induction or protection of limbic seizures in mice by mGluR subtype selective agonists.

Tizzano JP, Griffey KI, Schoepp DD. Tizzano JP, et al. Among authors: griffey ki. Neuropharmacology. 1995 Aug;34(8):1063-7. doi: 10.1016/0028-3908(95)00083-i. Neuropharmacology. 1995. PMID: 8532155

8

Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists.

Tizzano JP, Griffey KI, Johnson JA, Fix AS, Helton DR, Schoepp DD. Tizzano JP, et al. Among authors: griffey ki. Neurosci Lett. 1993 Nov 12;162(1-2):12-6. doi: 10.1016/0304-3940(93)90548-y. Neurosci Lett. 1993. PMID: 8121613

9

Neonatal exposure to D,L-2-amino-3-phosphonopropionate (D,L-AP3) produces lesions in the eye and optic nerve of adult rats.

Fix AS, Schoepp DD, Olney JW, Vestre WA, Griffey KI, Johnson JA, Tizzano JP. Fix AS, et al. Among authors: griffey ki. Brain Res Dev Brain Res. 1993 Oct 15;75(2):223-33. doi: 10.1016/0165-3806(93)90027-8. Brain Res Dev Brain Res. 1993. PMID: 8261613

10

Antidepressant-like actions of an AMPA receptor potentiator (LY392098).

Li X, Tizzano JP, Griffey K, Clay M, Lindstrom T, Skolnick P. Li X, et al. Neuropharmacology. 2001 Jun;40(8):1028-33. doi: 10.1016/s0028-3908(00)00194-5. Neuropharmacology. 2001. PMID: 11406194

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