Combs DW - Search Results

1

Benzoxazinones as PPARgamma agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model.

Rybczynski PJ, Zeck RE, Dudash J Jr, Combs DW, Burris TP, Yang M, Osborne MC, Chen X, Demarest KT. Rybczynski PJ, et al. Among authors: combs dw. J Med Chem. 2004 Jan 1;47(1):196-209. doi: 10.1021/jm0301888. J Med Chem. 2004. PMID: 14695833

2

Benzoxazinones as PPARgamma agonists. part 1: SAR of three aromatic regions.

Rybczynski PJ, Zeck RE, Combs DW, Turchi I, Burris TP, Xu JZ, Yang M, Demarest KT. Rybczynski PJ, et al. Among authors: combs dw. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2359-62. doi: 10.1016/s0960-894x(03)00401-3. Bioorg Med Chem Lett. 2003. PMID: 12824034

3

gamma-Aminobutyrate-A receptor modulation by 3-aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines.

Rybczynski PJ, Combs DW, Jacobs K, Shank RP, Dubinsky B. Rybczynski PJ, et al. Among authors: combs dw. J Med Chem. 1999 Jul 1;42(13):2403-8. doi: 10.1021/jm9805889. J Med Chem. 1999. PMID: 10395481

4

Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists.

Johnson SG, Gunnet JW, Moore JB, Miller W, Wines P, Rivero RA, Combs D, Demarest KT. Johnson SG, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3362-6. doi: 10.1016/j.bmcl.2006.04.017. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16650762

5

Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists.

Xiang MA, Chen RH, Demarest KT, Gunnet J, Look R, Hageman W, Murray WV, Combs DW, Patel M. Xiang MA, et al. Among authors: combs dw. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2987-9. doi: 10.1016/j.bmcl.2004.02.103. Bioorg Med Chem Lett. 2004. PMID: 15125974

6

Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists.

Xiang MA, Chen RH, Demarest KT, Gunnet J, Look R, Hageman W, Murray WV, Combs DW, Rybczynski PJ, Patel M. Xiang MA, et al. Among authors: combs dw. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3143-6. doi: 10.1016/j.bmcl.2004.04.016. Bioorg Med Chem Lett. 2004. PMID: 15149662

7

Nonsteroidal progesterone receptor ligands. 2. High-affinity ligands with selectivity for bone cell progesterone receptors.

Combs DW, Reese K, Cornelius LA, Gunnet JW, Cryan EV, Granger KS, Jordan JJ, Demarest KT. Combs DW, et al. J Med Chem. 1995 Dec 8;38(25):4880-4. doi: 10.1021/jm00025a004. J Med Chem. 1995. PMID: 8523400

8

Heteroatom analogues of bemoradan: chemistry and cardiotonic activity of 1,4-benzothiazinylpyridazinones.

Combs DW, Rampulla MS, Demers JP, Falotico R, Moore JB. Combs DW, et al. J Med Chem. 1992 Jan;35(1):172-6. doi: 10.1021/jm00079a023. J Med Chem. 1992. PMID: 1732525

9

6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents.

Combs DW, Rampulla MS, Bell SC, Klaubert DH, Tobia AJ, Falotico R, Haertlein B, Lakas-Weiss C, Moore JB. Combs DW, et al. J Med Chem. 1990 Jan;33(1):380-6. doi: 10.1021/jm00163a061. J Med Chem. 1990. PMID: 2153210

10

Discovery of the first non-peptide antagonist of the motilin receptor.

Beavers MP, Gunnet JW, Hageman W, Miller W, Moore JB, Zhou L, Chen RH, Xiang A, Urbanski M, Combs DW, Mayo KH, Demarest KT. Beavers MP, et al. Among authors: combs dw. Drug Des Discov. 2001;17(3):243-51. Drug Des Discov. 2001. PMID: 11469754

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