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The role of metabolic activation in drug-induced hepatotoxicity.
Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP. Park BK, et al. Among authors: williams dp. Annu Rev Pharmacol Toxicol. 2005;45:177-202. doi: 10.1146/annurev.pharmtox.45.120403.100058. Annu Rev Pharmacol Toxicol. 2005. PMID: 15822174 Review.
Acyl glucuronides: the good, the bad and the ugly.
Regan SL, Maggs JL, Hammond TG, Lambert C, Williams DP, Park BK. Regan SL, et al. Among authors: williams dp. Biopharm Drug Dispos. 2010 Oct;31(7):367-95. doi: 10.1002/bdd.720. Biopharm Drug Dispos. 2010. PMID: 20830700 Review.
Managing the challenge of chemically reactive metabolites in drug development.
Park BK, Boobis A, Clarke S, Goldring CE, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S, Nicoll-Griffith DA, Obach RS, Routledge P, Smith DA, Tweedie DJ, Vermeulen N, Williams DP, Wilson ID, Baillie TA. Park BK, et al. Among authors: williams dp. Nat Rev Drug Discov. 2011 Apr;10(4):292-306. doi: 10.1038/nrd3408. Nat Rev Drug Discov. 2011. PMID: 21455238 Review.
Reactive metabolites and their role in drug reactions.
Naisbitt DJ, Williams DP, Pirmohamed M, Kitteringham NR, Park BK. Naisbitt DJ, et al. Among authors: williams dp. Curr Opin Allergy Clin Immunol. 2001 Aug;1(4):317-25. doi: 10.1097/01.all.0000011033.64625.5a. Curr Opin Allergy Clin Immunol. 2001. PMID: 11964707 Review.
Role of reactive metabolites in drug-induced hepatotoxicity.
Srivastava A, Maggs JL, Antoine DJ, Williams DP, Smith DA, Park BK. Srivastava A, et al. Among authors: williams dp. Handb Exp Pharmacol. 2010;(196):165-94. doi: 10.1007/978-3-642-00663-0_7. Handb Exp Pharmacol. 2010. PMID: 20020263 Review.
212 results