Takayama H - Search Results

1

Remarkable effect of 2[small alpha]-modification on the VDR antagonistic activity of 1small alpha-hydroxyvitamin D3-26,23-lactones.

Saito N, Matsunaga T, Fujishima T, Anzai M, Saito H, Takenouchi K, Miura D, Ishizuka S, Takayama H, Kittaka A. Saito N, et al. Among authors: takayama h. Org Biomol Chem. 2003 Dec 21;1(24):4396-402. doi: 10.1039/b311107e. Epub 2003 Nov 6. Org Biomol Chem. 2003. PMID: 14685312

2

Synthesis and testing of 2alpha-modified 1alpha,25-dihydroxyvitamin D(3) analogues with a double side chain: marked cell differentiation activity.

Suhara Y, Kittaka A, Kishimoto S, Calverley MJ, Fujishima T, Saito N, Sugiura T, Waku K, Takayama H. Suhara Y, et al. Among authors: takayama h. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3255-8. doi: 10.1016/s0960-894x(02)00722-9. Bioorg Med Chem Lett. 2002. PMID: 12392726

3

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs.

Takayama H, Kittaka A, Fujishima T, Suhara Y. Takayama H, et al. Recent Results Cancer Res. 2003;164:289-317. doi: 10.1007/978-3-642-55580-0_21. Recent Results Cancer Res. 2003. PMID: 12899530 Review.

4

Design and synthesis of potent vitamin D receptor antagonists with A-ring modifications: remarkable effects of 2alpha-methyl introduction on antagonistic activity.

Fujishima T, Kojima Y, Azumaya I, Kittaka A, Takayama H. Fujishima T, et al. Among authors: takayama h. Bioorg Med Chem. 2003 Aug 15;11(17):3621-31. doi: 10.1016/s0968-0896(03)00371-7. Bioorg Med Chem. 2003. PMID: 12901907

5

Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators.

Fujishima T, Kittaka A, Yamaoka K, Takeyama K, Kato S, Takayama H. Fujishima T, et al. Among authors: takayama h. Org Biomol Chem. 2003 Jun 7;1(11):1863-9. doi: 10.1039/b302017g. Org Biomol Chem. 2003. PMID: 12945766

6

Efficient synthesis of 2-modified 1alpha,25-dihydroxy-19-norvitamin D3 with Julia olefination: high potency in induction of differentiation on HL-60 cells.

Ono K, Yoshida A, Saito N, Fujishima T, Honzawa S, Suhara Y, Kishimoto S, Sugiura T, Waku K, Takayama H, Kittaka A. Ono K, et al. Among authors: takayama h. J Org Chem. 2003 Sep 19;68(19):7407-15. doi: 10.1021/jo034787y. J Org Chem. 2003. PMID: 12968893

7

Concise synthesis and biological activities of 2alpha-alkyl- and 2alpha-(omega-hydroxyalkyl)-20-epi-1alpha,25-dihydroxyvitamin D3.

Honzawa S, Suhara Y, Nihei K, Saito N, Kishimoto S, Fujishima T, Kurihara M, Sugiura T, Waku K, Takayama H, Kittaka A. Honzawa S, et al. Among authors: takayama h. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3503-6. doi: 10.1016/s0960-894x(03)00739-x. Bioorg Med Chem Lett. 2003. PMID: 14505658

8

Dramatic enhancement of antagonistic activity on vitamin D receptor: a double functionalization of 1alpha-hydroxyvitamin D3 26,23-lactones.

Saito N, Saito H, Anzai M, Yoshida A, Fujishima T, Takenouchi K, Miura D, Ishizuka S, Takayama H, Kittaka A. Saito N, et al. Among authors: takayama h. Org Lett. 2003 Dec 11;5(25):4859-62. doi: 10.1021/ol035922w. Org Lett. 2003. PMID: 14653692

9

2,2-Functionalized analogues of 1alpha,25-dihydroxyvitamin D3, the potent inducers of cell differentiation.

Fujishima T, Kittaka A, Kurihara M, Saito N, Honzawa S, Kishimoto S, Sugiura T, Waku K, Takayama H. Fujishima T, et al. Among authors: takayama h. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):89-92. doi: 10.1016/j.jsbmb.2004.03.053. J Steroid Biochem Mol Biol. 2004. PMID: 15225752

10

Design and efficient synthesis of 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D3 Analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity.

Saito N, Suhara Y, Kurihara M, Fujishima T, Honzawa S, Takayanagi H, Kozono T, Matsumoto M, Ohmori M, Miyata N, Takayama H, Kittaka A. Saito N, et al. Among authors: takayama h. J Org Chem. 2004 Oct 29;69(22):7463-71. doi: 10.1021/jo0491051. J Org Chem. 2004. PMID: 15497970

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