Schaus JM - Search Results

1

Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists.

Mathes BM, Hudziak KJ, Schaus JM, Xu YC, Nelson DL, Wainscott DB, Nutter SE, Gough WH, Branchek TA, Zgombick JM, Filla SA. Mathes BM, et al. Among authors: schaus jm. Bioorg Med Chem Lett. 2004 Jan 5;14(1):167-70. doi: 10.1016/j.bmcl.2003.09.091. Bioorg Med Chem Lett. 2004. PMID: 14684321

2

Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.

Filla SA, Mathes BM, Johnson KW, Phebus LA, Cohen ML, Nelson DL, Zgombick JM, Erickson JA, Schenck KW, Wainscott DB, Branchek TA, Schaus JM. Filla SA, et al. Among authors: schaus jm. J Med Chem. 2003 Jul 3;46(14):3060-71. doi: 10.1021/jm030020m. J Med Chem. 2003. PMID: 12825944

3

Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists.

Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC. Zhang D, et al. Among authors: schaus jm. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6011-6. doi: 10.1016/j.bmcl.2004.09.079. Bioorg Med Chem Lett. 2004. PMID: 15546719

4

[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties.

Wainscott DB, Krushinski JH Jr, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL. Wainscott DB, et al. Among authors: schaus jm. Naunyn Schmiedebergs Arch Pharmacol. 2005 Mar;371(3):169-77. doi: 10.1007/s00210-005-1035-9. Epub 2005 Apr 27. Naunyn Schmiedebergs Arch Pharmacol. 2005. PMID: 15900510

5

Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists.

Krushinski JH Jr, Schaus JM, Thompson DC, Calligaro DO, Nelson DL, Luecke SH, Wainscott DB, Wong DT. Krushinski JH Jr, et al. Among authors: schaus jm. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5600-4. doi: 10.1016/j.bmcl.2007.07.086. Epub 2007 Aug 22. Bioorg Med Chem Lett. 2007. PMID: 17804228

6

Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT₁ F receptor agonists: Evolution from bicyclic to monocyclic cores.

Zhang D, Blanco MJ, Ying BP, Kohlman D, Liang SX, Victor F, Chen Q, Krushinski J, Filla SA, Hudziak KJ, Mathes BM, Cohen MP, Zacherl D, Nelson DL, Wainscott DB, Nutter SE, Gough WH, Schaus JM, Xu YC. Zhang D, et al. Among authors: schaus jm. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4337-41. doi: 10.1016/j.bmcl.2015.07.042. Epub 2015 Jul 22. Bioorg Med Chem Lett. 2015. PMID: 26271587

7

N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist.

Xu YC, Schaus JM, Walker C, Krushinski J, Adham N, Zgombick JM, Liang SX, Kohlman DT, Audia JE. Xu YC, et al. Among authors: schaus jm. J Med Chem. 1999 Feb 11;42(3):526-31. doi: 10.1021/jm9805945. J Med Chem. 1999. PMID: 9986723

8

N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.

Xu YC, Johnson KW, Phebus LA, Cohen M, Nelson DL, Schenck K, Walker CD, Fritz JE, Kaldor SW, LeTourneau ME, Murff RE, Zgombick JM, Calligaro DO, Audia JE, Schaus JM. Xu YC, et al. Among authors: schaus jm. J Med Chem. 2001 Nov 22;44(24):4031-4. doi: 10.1021/jm0155190. J Med Chem. 2001. PMID: 11708905

9

Human 5-HT1F receptor-stimulated [35S]GTPgammaS binding: correlation with inhibition of guinea pig dural plasma protein extravasation.

Wainscott DB, Johnson KW, Phebus LA, Schaus JM, Nelson DL. Wainscott DB, et al. Among authors: schaus jm. Eur J Pharmacol. 1998 Jul 3;352(1):117-24. doi: 10.1016/s0014-2999(98)00336-7. Eur J Pharmacol. 1998. PMID: 9718276

10

[3H]LY334370, a novel radioligand for the 5-HT1F receptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain.

Lucaites VL, Krushinski JH, Schaus JM, Audia JE, Nelson DL. Lucaites VL, et al. Among authors: schaus jm. Naunyn Schmiedebergs Arch Pharmacol. 2005 Mar;371(3):178-84. doi: 10.1007/s00210-005-1036-8. Epub 2005 Apr 27. Naunyn Schmiedebergs Arch Pharmacol. 2005. PMID: 15900511

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