Rote WE - Search Results

1

Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys.

Geisbert TW, Hensley LE, Jahrling PB, Larsen T, Geisbert JB, Paragas J, Young HA, Fredeking TM, Rote WE, Vlasuk GP. Geisbert TW, et al. Among authors: rote we. Lancet. 2003 Dec 13;362(9400):1953-8. doi: 10.1016/S0140-6736(03)15012-X. Lancet. 2003. PMID: 14683653

2

Inhibition of factor VIIa/tissue factor with nematode anticoagulant protein c2: from unique mechanism to a promising new clinical anticoagulant.

Vlasuk GP, Rote WE. Vlasuk GP, et al. Among authors: rote we. Trends Cardiovasc Med. 2002 Nov;12(8):325-31. doi: 10.1016/s1050-1738(02)00185-8. Trends Cardiovasc Med. 2002. PMID: 12536118 Review.

3

Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects.

de Jonge E, Friederich PW, Vlasuk GP, Rote WE, Vroom MB, Levi M, van der Poll T. de Jonge E, et al. Among authors: rote we. Clin Diagn Lab Immunol. 2003 May;10(3):495-7. doi: 10.1128/cdli.10.3.495-497.2003. Clin Diagn Lab Immunol. 2003. PMID: 12738659 Free PMC article.

4

Pharmacokinetics and anticoagulant properties of the factor VIIa-tissue factor inhibitor recombinant Nematode Anticoagulant Protein c2 following subcutaneous administration in man. Dependence on the stoichiometric binding to circulating factor X.

Vlasuk GP, Bradbury A, Lopez-Kinninger L, Colón S, Bergum PW, Maki S, Rote WE. Vlasuk GP, et al. Among authors: rote we. Thromb Haemost. 2003 Nov;90(5):803-12. doi: 10.1160/TH03-05-0265. Thromb Haemost. 2003. PMID: 14597974 Clinical Trial.

5

Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice.

Weijer S, Schoenmakers SH, Florquin S, Levi M, Vlasuk GP, Rote WE, Reitsma PH, Spek CA, van der Poll T. Weijer S, et al. Among authors: rote we. J Infect Dis. 2004 Jun 15;189(12):2308-17. doi: 10.1086/421031. Epub 2004 May 25. J Infect Dis. 2004. PMID: 15181580

6

Recombinant nematode anticoagulant protein c2, an inhibitor of the tissue factor/factor VIIa complex, in patients undergoing elective coronary angioplasty.

Moons AH, Peters RJ, Bijsterveld NR, Piek JJ, Prins MH, Vlasuk GP, Rote WE, Büller HR. Moons AH, et al. Among authors: rote we. J Am Coll Cardiol. 2003 Jun 18;41(12):2147-53. doi: 10.1016/s0735-1097(03)00478-9. J Am Coll Cardiol. 2003. PMID: 12821239 Free article. Clinical Trial.

7

Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism.

Hembrough TA, Swartz GM, Papathanassiu A, Vlasuk GP, Rote WE, Green SJ, Pribluda VS. Hembrough TA, et al. Among authors: rote we. Cancer Res. 2003 Jun 1;63(11):2997-3000. Cancer Res. 2003. PMID: 12782609

8

Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia.

Rijneveld AW, Weijer S, Bresser P, Florquin S, Vlasuk GP, Rote WE, Spek CA, Reitsma PH, van der Zee JS, Levi M, van der Poll T. Rijneveld AW, et al. Among authors: rote we. Crit Care Med. 2006 Jun;34(6):1725-30. doi: 10.1097/01.CCM.0000218807.20570.C2. Crit Care Med. 2006. PMID: 16625114

9

Ability of recombinant factor VIIa to generate thrombin during inhibition of tissue factor in human subjects.

Friederich PW, Levi M, Bauer KA, Vlasuk GP, Rote WE, Breederveld D, Keller T, Spataro M, Barzegar S, Büller HR. Friederich PW, et al. Among authors: rote we. Circulation. 2001 May 29;103(21):2555-9. doi: 10.1161/01.cir.103.21.2555. Circulation. 2001. PMID: 11382723 Clinical Trial.

10

Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin-10 response in human endotoxemia.

de Pont AC, Moons AH, de Jonge E, Meijers JC, Vlasuk GP, Rote WE, Büller HR, van der Poll T, Levi M. de Pont AC, et al. Among authors: rote we. J Thromb Haemost. 2004 Jan;2(1):65-70. doi: 10.1111/j.1538-7836.2004.00526.x. J Thromb Haemost. 2004. PMID: 14717968 Free article. Clinical Trial.

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