Mutagenesis of key residues identifies the connection subdomain of HIV-1 reverse transcriptase as the site of inhibition by heme.
Argyris EG, Vanderkooi JM, Paterson Y.
Argyris EG, et al.
Eur J Biochem. 2001 Feb;268(4):925-31. doi: 10.1046/j.1432-1327.2001.01944.x.
Eur J Biochem. 2001.
PMID: 11179958
Free article.
We have recently demonstrated that metalloporphyrins are potent inhibitors of both human immunodeficiency virus type 1 (HIV-1) and human immunodeficiency virus type 2 (HIV-2) reverse transcriptases (RTs) [Argyris, E.G., Vanderkooi, J.M., Venkateswaran, P.S., Kay, B. …
We have recently demonstrated that metalloporphyrins are potent inhibitors of both human immunodeficiency virus type 1 (HIV-1) and human imm …