O'Brate A - Search Results

1

Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation.

Nicolaou KC, Li Y, Sugita K, Monenschein H, Guntupalli P, Mitchell HJ, Fylaktakidou KC, Vourloumis D, Giannakakou P, O'Brate A. Nicolaou KC, et al. J Am Chem Soc. 2003 Dec 17;125(50):15443-54. doi: 10.1021/ja030496v. J Am Chem Soc. 2003. PMID: 14664590

2

Total synthesis and biological evaluation of (-)apicularen A and analogues thereof.

Nicolaou KC, Kim DW, Baati R, O'Brate A, Giannakakou P. Nicolaou KC, et al. Chemistry. 2003 Dec 15;9(24):6177-91. doi: 10.1002/chem.200305230. Chemistry. 2003. PMID: 14679529

3

Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure.

Nicolaou KC, Snyder SA, Giuseppone N, Huang X, Bella M, Reddy MV, Rao PB, Koumbis AE, O'Brate A, Giannakakou P. Nicolaou KC, et al. J Am Chem Soc. 2004 Aug 18;126(32):10174-82. doi: 10.1021/ja040091q. J Am Chem Soc. 2004. PMID: 15303893

4

Chemistry and biology of diazonamide A: second total synthesis and biological investigations.

Nicolaou KC, Hao J, Reddy MV, Rao PB, Rassias G, Snyder SA, Huang X, Chen DY, Brenzovich WE, Giuseppone N, O'Brate A, Giannakakou P. Nicolaou KC, et al. J Am Chem Soc. 2004 Oct 13;126(40):12897-906. doi: 10.1021/ja040093a. J Am Chem Soc. 2004. PMID: 15469287

5

Discovery of a biologically active thiostrepton fragment.

Nicolaou KC, Zak M, Rahimipour S, Estrada AA, Lee SH, O'Brate A, Giannakakou P, Ghadiri MR. Nicolaou KC, et al. J Am Chem Soc. 2005 Nov 2;127(43):15042-4. doi: 10.1021/ja0552803. J Am Chem Soc. 2005. PMID: 16248640

6

Design, synthesis, and biological properties of highly potent epothilone B analogues.

Nicolaou KC, Sasmal PK, Rassias G, Reddy MV, Altmann KH, Wartmann M, O'Brate A, Giannakakou P. Nicolaou KC, et al. Angew Chem Int Ed Engl. 2003 Aug 4;42(30):3515-20. doi: 10.1002/anie.200351819. Angew Chem Int Ed Engl. 2003. PMID: 12900969 No abstract available.

7

Molecular design and chemical synthesis of a highly potent epothilone.

Nicolaou KC, Pratt BA, Arseniyadis S, Wartmann M, O'Brate A, Giannakakou P. Nicolaou KC, et al. Among authors: o brate a. ChemMedChem. 2006 Jan;1(1):41-4. doi: 10.1002/cmdc.200500056. ChemMedChem. 2006. PMID: 16892332 No abstract available.

8

The importance of p53 location: nuclear or cytoplasmic zip code?

O'Brate A, Giannakakou P. O'Brate A, et al. Drug Resist Updat. 2003 Dec;6(6):313-22. doi: 10.1016/j.drup.2003.10.004. Drug Resist Updat. 2003. PMID: 14744495 Review.

9

Survivin deregulation in beta-tubulin mutant ovarian cancer cells underlies their compromised mitotic response to taxol.

Zhou J, O'brate A, Zelnak A, Giannakakou P. Zhou J, et al. Cancer Res. 2004 Dec 1;64(23):8708-14. doi: 10.1158/0008-5472.CAN-04-2538. Cancer Res. 2004. PMID: 15574781

10

Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity.

Buey RM, Díaz JF, Andreu JM, O'Brate A, Giannakakou P, Nicolaou KC, Sasmal PK, Ritzén A, Namoto K. Buey RM, et al. Chem Biol. 2004 Feb;11(2):225-36. doi: 10.1016/j.chembiol.2004.01.014. Chem Biol. 2004. PMID: 15123284

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