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Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface.
Wooldridge L, Hutchinson SL, Choi EM, Lissina A, Jones E, Mirza F, Dunbar PR, Price DA, Cerundolo V, Sewell AK. Wooldridge L, et al. Among authors: hutchinson sl. J Immunol. 2003 Dec 15;171(12):6650-60. doi: 10.4049/jimmunol.171.12.6650. J Immunol. 2003. PMID: 14662868
Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.
Chen JL, Morgan AJ, Stewart-Jones G, Shepherd D, Bossi G, Wooldridge L, Hutchinson SL, Sewell AK, Griffiths GM, van der Merwe PA, Jones EY, Galione A, Cerundolo V. Chen JL, et al. Among authors: hutchinson sl. J Immunol. 2010 Feb 15;184(4):1829-1839. doi: 10.4049/jimmunol.0902103. Epub 2010 Jan 6. J Immunol. 2010. PMID: 20053942 Free PMC article.
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
Glick M, Price DA, Vuidepot AL, Andersen TB, Hutchinson SL, Laugel B, Sewell AK, Boulter JM, Dunbar PR, Cerundolo V, Oxenius A, Bell JI, Richards WG, Jakobsen BK. Glick M, et al. Among authors: hutchinson sl. J Biol Chem. 2002 Jun 7;277(23):20840-6. doi: 10.1074/jbc.M201819200. Epub 2002 Mar 25. J Biol Chem. 2002. PMID: 11914379 Free article.
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.
Wooldridge L, van den Berg HA, Glick M, Gostick E, Laugel B, Hutchinson SL, Milicic A, Brenchley JM, Douek DC, Price DA, Sewell AK. Wooldridge L, et al. Among authors: hutchinson sl. J Biol Chem. 2005 Jul 29;280(30):27491-501. doi: 10.1074/jbc.M500555200. Epub 2005 Apr 18. J Biol Chem. 2005. PMID: 15837791 Free PMC article.
35 results