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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. Jankowsky JL, et al. Among authors: younkin lh, younkin sg. Hum Mol Genet. 2004 Jan 15;13(2):159-70. doi: 10.1093/hmg/ddh019. Epub 2003 Nov 25. Hum Mol Genet. 2004. PMID: 14645205
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Ertekin-Taner N, Ronald J, Asahara H, Younkin L, Hella M, Jain S, Gnida E, Younkin S, Fadale D, Ohyagi Y, Singleton A, Scanlin L, de Andrade M, Petersen R, Graff-Radford N, Hutton M, Younkin S. Ertekin-Taner N, et al. Hum Mol Genet. 2003 Dec 1;12(23):3133-43. doi: 10.1093/hmg/ddg343. Epub 2003 Oct 14. Hum Mol Genet. 2003. PMID: 14559775 Free PMC article.
Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.
Ertekin-Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, Hella M, Jain S, Hackett A, Scanlin L, Kelly J, Kihiko-Ehman M, Neltner M, Hersh L, Kindy M, Markesbery W, Hutton M, de Andrade M, Petersen RC, Graff-Radford N, Estus S, Brookes AJ, Younkin SG. Ertekin-Taner N, et al. Hum Mol Genet. 2005 Feb 1;14(3):447-60. doi: 10.1093/hmg/ddi041. Epub 2004 Dec 22. Hum Mol Genet. 2005. PMID: 15615772
Serum creatinine levels correlate with plasma amyloid Beta protein.
Arvanitakis Z, Lucas JA, Younkin LH, Younkin SG, Graff-Radford NR. Arvanitakis Z, et al. Among authors: younkin lh, younkin sg. Alzheimer Dis Assoc Disord. 2002 Jul-Sep;16(3):187-90. doi: 10.1097/00002093-200207000-00009. Alzheimer Dis Assoc Disord. 2002. PMID: 12218650
75 results