Wagner SL - Search Results

1

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. Jankowsky JL, et al. Among authors: wagner sl. Hum Mol Genet. 2004 Jan 15;13(2):159-70. doi: 10.1093/hmg/ddh019. Epub 2003 Nov 25. Hum Mol Genet. 2004. PMID: 14645205

2

Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.

Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS. Lo AC, et al. Among authors: wagner sl. J Biol Chem. 1994 Dec 9;269(49):30966-73. J Biol Chem. 1994. PMID: 7983032 Free article.

3

Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.

Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD. Lamb BT, et al. Among authors: wagner sl. Hum Mol Genet. 1997 Sep;6(9):1535-41. doi: 10.1093/hmg/6.9.1535. Hum Mol Genet. 1997. PMID: 9285791

4

Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits.

Anderson JJ, Holtz G, Baskin PP, Wang R, Mazzarelli L, Wagner SL, Menzaghi F. Anderson JJ, et al. Among authors: wagner sl. Neuroscience. 1999;93(4):1409-20. doi: 10.1016/s0306-4522(99)00244-4. Neuroscience. 1999. PMID: 10501466

5

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.

Lesuisse C, Xu G, Anderson J, Wong M, Jankowsky J, Holtz G, Gonzalez V, Wong PC, Price DL, Tang F, Wagner S, Borchelt DR. Lesuisse C, et al. Hum Mol Genet. 2001 Oct 15;10(22):2525-37. doi: 10.1093/hmg/10.22.2525. Hum Mol Genet. 2001. PMID: 11709540

6

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. Kim M, et al. Among authors: wagner sl. Hum Mol Genet. 2009 Oct 15;18(20):3987-96. doi: 10.1093/hmg/ddp323. Epub 2009 Jul 15. Hum Mol Genet. 2009. PMID: 19608551 Free PMC article.

7

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.

Lamb BT, Bardel KA, Kulnane LS, Anderson JJ, Holtz G, Wagner SL, Sisodia SS, Hoeger EJ. Lamb BT, et al. Among authors: wagner sl. Nat Neurosci. 1999 Aug;2(8):695-7. doi: 10.1038/11154. Nat Neurosci. 1999. PMID: 10412057 No abstract available.

8

Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL. Anderson JJ, et al. Among authors: wagner sl. Biochem Pharmacol. 2005 Feb 15;69(4):689-98. doi: 10.1016/j.bcp.2004.11.015. Epub 2005 Jan 7. Biochem Pharmacol. 2005. PMID: 15670587

9

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Kounnas MZ, et al. Among authors: wagner sl. Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018. Neuron. 2010. PMID: 20826309 Free PMC article.

10

Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion.

Zeiger W, Vetrivel KS, Buggia-Prévot V, Nguyen PD, Wagner SL, Villereal ML, Thinakaran G. Zeiger W, et al. Among authors: wagner sl. J Biol Chem. 2013 Sep 13;288(37):26955-66. doi: 10.1074/jbc.M113.473355. Epub 2013 Jul 31. J Biol Chem. 2013. PMID: 23902769 Free PMC article.

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