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mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.
Hannan KM, Brandenburger Y, Jenkins A, Sharkey K, Cavanaugh A, Rothblum L, Moss T, Poortinga G, McArthur GA, Pearson RB, Hannan RD. Hannan KM, et al. Among authors: sharkey k. Mol Cell Biol. 2003 Dec;23(23):8862-77. doi: 10.1128/MCB.23.23.8862-8877.2003. Mol Cell Biol. 2003. PMID: 14612424 Free PMC article.
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation.
Poortinga G, Hannan KM, Snelling H, Walkley CR, Jenkins A, Sharkey K, Wall M, Brandenburger Y, Palatsides M, Pearson RB, McArthur GA, Hannan RD. Poortinga G, et al. Among authors: sharkey k. EMBO J. 2004 Aug 18;23(16):3325-35. doi: 10.1038/sj.emboj.7600335. Epub 2004 Jul 29. EMBO J. 2004. PMID: 15282543 Free PMC article.
UBF levels determine the number of active ribosomal RNA genes in mammals.
Sanij E, Poortinga G, Sharkey K, Hung S, Holloway TP, Quin J, Robb E, Wong LH, Thomas WG, Stefanovsky V, Moss T, Rothblum L, Hannan KM, McArthur GA, Pearson RB, Hannan RD. Sanij E, et al. Among authors: sharkey k. J Cell Biol. 2008 Dec 29;183(7):1259-74. doi: 10.1083/jcb.200805146. Epub 2008 Dec 22. J Cell Biol. 2008. PMID: 19103806 Free PMC article.
463 results