Sinclair DA - Search Results

1

Yeast life-span extension by calorie restriction is independent of NAD fluctuation.

Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA. Anderson RM, et al. Among authors: sinclair da. Science. 2003 Dec 19;302(5653):2124-2126. doi: 10.1126/science.1088697. Epub 2003 Nov 6. Science. 2003. PMID: 14605207 Free PMC article.

2

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.

Sinclair DA, Mills K, Guarente L. Sinclair DA, et al. Science. 1997 Aug 29;277(5330):1313-6. doi: 10.1126/science.277.5330.1313. Science. 1997. PMID: 9271578

3

Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.

Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Anderson RM, et al. Among authors: sinclair da. J Biol Chem. 2002 May 24;277(21):18881-90. doi: 10.1074/jbc.M111773200. Epub 2002 Mar 7. J Biol Chem. 2002. PMID: 11884393 Free article.

4

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Bitterman KJ, et al. Among authors: sinclair da. J Biol Chem. 2002 Nov 22;277(47):45099-107. doi: 10.1074/jbc.M205670200. Epub 2002 Sep 23. J Biol Chem. 2002. PMID: 12297502 Free article.

5

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.

Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Anderson RM, et al. Among authors: sinclair da. Nature. 2003 May 8;423(6936):181-5. doi: 10.1038/nature01578. Nature. 2003. PMID: 12736687 Free PMC article.

6

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Howitz KT, et al. Among authors: sinclair da. Nature. 2003 Sep 11;425(6954):191-6. doi: 10.1038/nature01960. Epub 2003 Aug 24. Nature. 2003. PMID: 12939617

7

Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.

Bitterman KJ, Medvedik O, Sinclair DA. Bitterman KJ, et al. Among authors: sinclair da. Microbiol Mol Biol Rev. 2003 Sep;67(3):376-99, table of contents. doi: 10.1128/MMBR.67.3.376-399.2003. Microbiol Mol Biol Rev. 2003. PMID: 12966141 Free PMC article. Review.

8

Cell biology. An age of instability.

Sinclair DA. Sinclair DA. Science. 2003 Sep 26;301(5641):1859-60. doi: 10.1126/science.1090465. Science. 2003. PMID: 14512612

9

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Brunet A, et al. Among authors: sinclair da. Science. 2004 Mar 26;303(5666):2011-5. doi: 10.1126/science.1094637. Epub 2004 Feb 19. Science. 2004. PMID: 14976264

10

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.

Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA. Cohen HY, et al. Among authors: sinclair da. Mol Cell. 2004 Mar 12;13(5):627-38. doi: 10.1016/s1097-2765(04)00094-2. Mol Cell. 2004. PMID: 15023334 Free article.

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