Moshinsky DJ - Search Results

1

A widely applicable, high-throughput TR-FRET assay for the measurement of kinase autophosphorylation: VEGFR-2 as a prototype.

Moshinsky DJ, Ruslim L, Blake RA, Tang F. Moshinsky DJ, et al. J Biomol Screen. 2003 Aug;8(4):447-52. doi: 10.1177/1087057103255282. J Biomol Screen. 2003. PMID: 14567797

2

A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability.

Patel N, Sun L, Moshinsky D, Chen H, Leahy KM, Le P, Moss KG, Wang X, Rice A, Tam D, Laird AD, Yu X, Zhang Q, Tang C, McMahon G, Howlett A. Patel N, et al. J Pharmacol Exp Ther. 2003 Sep;306(3):838-45. doi: 10.1124/jpet.103.052167. Epub 2003 May 23. J Pharmacol Exp Ther. 2003. PMID: 12766257

3

High-throughput biochemical kinase selectivity assays: panel development and screening applications.

Card A, Caldwell C, Min H, Lokchander B, Hualin Xi, Sciabola S, Kamath AV, Clugston SL, Tschantz WR, Leyu Wang, Moshinsky DJ. Card A, et al. Among authors: moshinsky dj. J Biomol Screen. 2009 Jan;14(1):31-42. doi: 10.1177/1087057108326663. Epub 2008 Dec 10. J Biomol Screen. 2009. PMID: 19073965

4

SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2.

Moshinsky DJ, Bellamacina CR, Boisvert DC, Huang P, Hui T, Jancarik J, Kim SH, Rice AG. Moshinsky DJ, et al. Biochem Biophys Res Commun. 2003 Oct 24;310(3):1026-31. doi: 10.1016/j.bbrc.2003.09.114. Biochem Biophys Res Commun. 2003. PMID: 14550307

5

Predicting kinase selectivity profiles using Free-Wilson QSAR analysis.

Sciabola S, Stanton RV, Wittkopp S, Wildman S, Moshinsky D, Potluri S, Xi H. Sciabola S, et al. J Chem Inf Model. 2008 Sep;48(9):1851-67. doi: 10.1021/ci800138n. Epub 2008 Aug 22. J Chem Inf Model. 2008. PMID: 18717582

6

Prediction of specificity-determining residues for small-molecule kinase inhibitors.

Caffrey DR, Lunney EA, Moshinsky DJ. Caffrey DR, et al. Among authors: moshinsky dj. BMC Bioinformatics. 2008 Nov 25;9:491. doi: 10.1186/1471-2105-9-491. BMC Bioinformatics. 2008. PMID: 19032760 Free PMC article.

7

Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

Tecle H, Shao J, Li Y, Kothe M, Kazmirski S, Penzotti J, Ding YH, Ohren J, Moshinsky D, Coli R, Jhawar N, Bora E, Jacques-O'Hagan S, Wu J. Tecle H, et al. Bioorg Med Chem Lett. 2009 Jan 1;19(1):226-9. doi: 10.1016/j.bmcl.2008.10.108. Epub 2008 Oct 31. Bioorg Med Chem Lett. 2009. PMID: 19019675

8

The specificity of JAK3 kinase inhibitors.

Changelian PS, Moshinsky D, Kuhn CF, Flanagan ME, Munchhof MJ, Harris TM, Whipple DA, Doty JL, Sun J, Kent CR, Magnuson KS, Perregaux DG, Sawyer PS, Kudlacz EM. Changelian PS, et al. Blood. 2008 Feb 15;111(4):2155-7. doi: 10.1182/blood-2007-09-115030. Epub 2007 Dec 19. Blood. 2008. PMID: 18094329 Free article.

9

SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization.

Ismail IH, Mårtensson S, Moshinsky D, Rice A, Tang C, Howlett A, McMahon G, Hammarsten O. Ismail IH, et al. Oncogene. 2004 Jan 29;23(4):873-82. doi: 10.1038/sj.onc.1207303. Oncogene. 2004. PMID: 14661061

10

Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling.

Zhong H, Zou H, Semenov MV, Moshinsky D, He X, Huang H, Li S, Quan J, Yang Z, Lin S. Zhong H, et al. Mol Biosyst. 2009 Nov;5(11):1356-60. doi: 10.1039/b905752h. Epub 2009 Aug 12. Mol Biosyst. 2009. PMID: 19823752 Free PMC article.

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