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Page 1
Different functional aspects of the group II subfamily (Types IIA and V) and type X secretory phospholipase A(2)s in regulating arachidonic acid release and prostaglandin generation. Implications of cyclooxygenase-2 induction and phospholipid scramblase-mediated cellular membrane perturbation.
Murakami M, Kambe T, Shimbara S, Higashino K, Hanasaki K, Arita H, Horiguchi M, Arita M, Arai H, Inoue K, Kudo I. Murakami M, et al. Among authors: horiguchi m. J Biol Chem. 1999 Oct 29;274(44):31435-44. doi: 10.1074/jbc.274.44.31435. J Biol Chem. 1999. PMID: 10531345 Free article.
Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors.
Watanabe H, Ishida K, Yamamoto M, Nakako T, Horiguchi M, Isobe Y. Watanabe H, et al. Among authors: horiguchi m. Bioorg Med Chem Lett. 2021 May 15;40:127911. doi: 10.1016/j.bmcl.2021.127911. Epub 2021 Mar 7. Bioorg Med Chem Lett. 2021. PMID: 33691168 No abstract available.
2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A.
Nishio Y, Kimura H, Sawada N, Sugaru E, Horiguchi M, Ono M, Furuta Y, Sakai M, Masui Y, Otani M, Hashizuka T, Honda Y, Deguchi J, Nakagawa T, Nakahira H. Nishio Y, et al. Among authors: horiguchi m. Bioorg Med Chem. 2011 Sep 15;19(18):5490-9. doi: 10.1016/j.bmc.2011.07.042. Epub 2011 Aug 4. Bioorg Med Chem. 2011. PMID: 21865048
Chronic administration of DSP-7238, a novel, potent, specific and substrate-selective DPP IV inhibitor, improves glycaemic control and beta-cell damage in diabetic mice.
Furuta Y, Horiguchi M, Sugaru E, Ono-Kishino M, Otani M, Sakai M, Masui Y, Tsuchida A, Sato Y, Takubo K, Hochigai H, Kimura H, Nakahira H, Nakagawa T, Taiji M. Furuta Y, et al. Among authors: horiguchi m. Diabetes Obes Metab. 2010 May;12(5):421-30. doi: 10.1111/j.1463-1326.2009.01180.x. Diabetes Obes Metab. 2010. PMID: 20415690
498 results