Shen A - Search Results

1

Determination of the rate of reduction of oxyferrous cytochrome P450 2B4 by 5-deazariboflavin adenine dinucleotide T491V cytochrome P450 reductase.

Zhang H, Gruenke L, Arscott D, Shen A, Kasper C, Harris DL, Glavanovich M, Johnson R, Waskell L. Zhang H, et al. Among authors: shen a. Biochemistry. 2003 Oct 14;42(40):11594-603. doi: 10.1021/bi034968u. Biochemistry. 2003. PMID: 14529269

2

Preparation and characterization of a 5'-deazaFAD T491V NADPH-cytochrome P450 reductase.

Zhang H, Gruenke L, Saribas AS, Im SC, Shen AL, Kasper CB, Waskell L. Zhang H, et al. Among authors: shen al. Biochemistry. 2003 Jun 10;42(22):6804-13. doi: 10.1021/bi030081m. Biochemistry. 2003. PMID: 12779335

3

Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.

Xia C, Rwere F, Im S, Shen AL, Waskell L, Kim JP. Xia C, et al. Biochemistry. 2018 Feb 13;57(6):945-962. doi: 10.1021/acs.biochem.7b01102. Epub 2018 Jan 30. Biochemistry. 2018. PMID: 29308883 Free PMC article.

4

Role of Ser457 of NADPH-cytochrome P450 oxidoreductase in catalysis and control of FAD oxidation-reduction potential.

Shen AL, Kasper CB. Shen AL, et al. Biochemistry. 1996 Jul 23;35(29):9451-9. doi: 10.1021/bi960587n. Biochemistry. 1996. PMID: 8755724

5

Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding.

Xia C, Hamdane D, Shen AL, Choi V, Kasper CB, Pearl NM, Zhang H, Im SC, Waskell L, Kim JJ. Xia C, et al. J Biol Chem. 2011 May 6;286(18):16246-60. doi: 10.1074/jbc.M111.230532. Epub 2011 Feb 23. J Biol Chem. 2011. PMID: 21345800 Free PMC article.

6

Differential contributions of NADPH-cytochrome P450 oxidoreductase FAD binding site residues to flavin binding and catalysis.

Shen AL, Kasper CB. Shen AL, et al. J Biol Chem. 2000 Dec 29;275(52):41087-91. doi: 10.1074/jbc.M008380200. J Biol Chem. 2000. PMID: 11022049 Free article.

7

Role of acidic residues in the interaction of NADPH-cytochrome P450 oxidoreductase with cytochrome P450 and cytochrome c.

Shen AL, Kasper CB. Shen AL, et al. J Biol Chem. 1995 Nov 17;270(46):27475-80. doi: 10.1074/jbc.270.46.27475. J Biol Chem. 1995. PMID: 7499204 Free article.

8

Mechanistic studies on the reductive half-reaction of NADPH-cytochrome P450 oxidoreductase.

Shen AL, Sem DS, Kasper CB. Shen AL, et al. J Biol Chem. 1999 Feb 26;274(9):5391-8. doi: 10.1074/jbc.274.9.5391. J Biol Chem. 1999. PMID: 10026149 Free article.

Earlier studies had shown that the S457A mutation decreased cytochrome c reductase activity 90-fold and also lowered the redox potential of the FAD semiquinone (Shen, A., and Kasper, C. B. (1996) Biochemistry 35, 9451-9459). The S457A/D675N and S457A/D675N/C630A mut …

Earlier studies had shown that the S457A mutation decreased cytochrome c reductase activity 90-fold and also lowered the redox potential of …

9

NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer.

Hubbard PA, Shen AL, Paschke R, Kasper CB, Kim JJ. Hubbard PA, et al. Among authors: shen al. J Biol Chem. 2001 Aug 3;276(31):29163-70. doi: 10.1074/jbc.M101731200. Epub 2001 May 22. J Biol Chem. 2001. PMID: 11371558 Free article.

10

31P NMR spectroscopic studies on purified, native and cloned, expressed forms of NADPH-cytochrome P450 reductase.

Narayanasami R, Otvos JD, Kasper CB, Shen A, Rajagopalan J, McCabe TJ, Okita JR, Hanahan DJ, Masters BS. Narayanasami R, et al. Among authors: shen a. Biochemistry. 1992 May 5;31(17):4210-8. doi: 10.1021/bi00132a009. Biochemistry. 1992. PMID: 1567869

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