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Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.
Burnett JC, Schmidt JJ, Stafford RG, Panchal RG, Nguyen TL, Hermone AR, Vennerstrom JL, McGrath CF, Lane DJ, Sausville EA, Zaharevitz DW, Gussio R, Bavari S. Burnett JC, et al. Among authors: gussio r. Biochem Biophys Res Commun. 2003 Oct 10;310(1):84-93. doi: 10.1016/j.bbrc.2003.08.112. Biochem Biophys Res Commun. 2003. PMID: 14511652
Identification of small molecule inhibitors of anthrax lethal factor.
Panchal RG, Hermone AR, Nguyen TL, Wong TY, Schwarzenbacher R, Schmidt J, Lane D, McGrath C, Turk BE, Burnett J, Aman MJ, Little S, Sausville EA, Zaharevitz DW, Cantley LC, Liddington RC, Gussio R, Bavari S. Panchal RG, et al. Among authors: gussio r. Nat Struct Mol Biol. 2004 Jan;11(1):67-72. doi: 10.1038/nsmb711. Epub 2003 Dec 29. Nat Struct Mol Biol. 2004. PMID: 14718925
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
Burnett JC, Ruthel G, Stegmann CM, Panchal RG, Nguyen TL, Hermone AR, Stafford RG, Lane DJ, Kenny TA, McGrath CF, Wipf P, Stahl AM, Schmidt JJ, Gussio R, Brunger AT, Bavari S. Burnett JC, et al. Among authors: gussio r. J Biol Chem. 2007 Feb 16;282(7):5004-5014. doi: 10.1074/jbc.M608166200. Epub 2006 Nov 8. J Biol Chem. 2007. PMID: 17092934 Free article.
A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.
Burnett JC, Opsenica D, Sriraghavan K, Panchal RG, Ruthel G, Hermone AR, Nguyen TL, Kenny TA, Lane DJ, McGrath CF, Schmidt JJ, Vennerstrom JL, Gussio R, Solaja BA, Bavari S. Burnett JC, et al. Among authors: gussio r. J Med Chem. 2007 May 3;50(9):2127-36. doi: 10.1021/jm061446e. Epub 2007 Apr 7. J Med Chem. 2007. PMID: 17417831
Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.
Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S. Kiris E, et al. Among authors: gussio r. PLoS One. 2015 Jun 10;10(6):e0129264. doi: 10.1371/journal.pone.0129264. eCollection 2015. PLoS One. 2015. PMID: 26061731 Free PMC article.
66 results