Ashe BM - Search Results

1

Orally active beta-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones.

Shah SK, Dorn CP Jr, Finke PE, Hale JJ, Hagmann WK, Brause KA, Chandler GO, Kissinger AL, Ashe BM, Weston H, et al. Shah SK, et al. Among authors: ashe bm. J Med Chem. 1992 Oct 16;35(21):3745-54. doi: 10.1021/jm00099a003. J Med Chem. 1992. PMID: 1433189

2

Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives.

Knight WB, Maycock AL, Green BG, Ashe BM, Gale P, Weston H, Finke PE, Hagmann WK, Shah SK, Doherty JB. Knight WB, et al. Among authors: ashe bm. Biochemistry. 1992 Jun 2;31(21):4980-6. doi: 10.1021/bi00136a010. Biochemistry. 1992. PMID: 1599924

3

A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster.

Fletcher DS, Osinga DG, Hand KM, Dellea PS, Ashe BM, Mumford RA, Davies P, Hagmann W, Finke PE, Doherty JB, et al. Fletcher DS, et al. Among authors: ashe bm. Am Rev Respir Dis. 1990 Mar;141(3):672-7. doi: 10.1164/ajrccm/141.3.672. Am Rev Respir Dis. 1990. PMID: 2310097

4

Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters.

Doherty JB, Ashe BM, Barker PL, Blacklock TJ, Butcher JW, Chandler GO, Dahlgren ME, Davies P, Dorn CP Jr, Finke PE, et al. Doherty JB, et al. Among authors: ashe bm. J Med Chem. 1990 Sep;33(9):2513-21. doi: 10.1021/jm00171a028. J Med Chem. 1990. PMID: 2391691

5

Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides.

Finke PE, Ashe BM, Knight WB, Maycock AL, Navia MA, Shah SK, Thompson KR, Underwood DJ, Weston H, Zimmerman M, et al. Finke PE, et al. Among authors: ashe bm. J Med Chem. 1990 Sep;33(9):2522-8. doi: 10.1021/jm00171a029. J Med Chem. 1990. PMID: 2391692

6

Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins.

Shah SK, Brause KA, Chandler GO, Finke PE, Ashe BM, Weston H, Knight WB, Maycock AL, Doherty JB. Shah SK, et al. Among authors: ashe bm. J Med Chem. 1990 Sep;33(9):2529-35. doi: 10.1021/jm00171a030. J Med Chem. 1990. PMID: 2391693

7

Orally active beta-lactam inhibitors of human leukocyte elastase. 3. Stereospecific synthesis and structure-activity relationships for 3,3-dialkylazetidin-2-ones.

Finke PE, Shah SK, Fletcher DS, Ashe BM, Brause KA, Chandler GO, Dellea PS, Hand KM, Maycock AL, Osinga DG, et al. Finke PE, et al. Among authors: ashe bm. J Med Chem. 1995 Jun 23;38(13):2449-62. doi: 10.1021/jm00013a021. J Med Chem. 1995. PMID: 7608910

8

Orally active beta-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution.

Hagmann WK, Kissinger AL, Shah SK, Finke PE, Dorn CP, Brause KA, Ashe BM, Weston H, Maycock AL, Knight WB, et al. Hagmann WK, et al. Among authors: ashe bm. J Med Chem. 1993 Mar 19;36(6):771-7. doi: 10.1021/jm00058a015. J Med Chem. 1993. PMID: 8459404

9

Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol.

Finke PE, Shah SK, Ashe BM, Ball RG, Blacklock TJ, Bonney RJ, Brause KA, Chandler GO, Cotton M, Davies P, et al. Finke PE, et al. Among authors: ashe bm. J Med Chem. 1992 Oct 16;35(21):3731-44. doi: 10.1021/jm00099a002. J Med Chem. 1992. PMID: 1433188

10

Proteinase inhibitors. I. Inhibitors of elastase.

Dorn CP, Zimmerman M, Yang SS, Yurewicz EC, Ashe BM, Frankshun R, Jones H. Dorn CP, et al. Among authors: ashe bm. J Med Chem. 1977 Nov;20(11):1464-8. doi: 10.1021/jm00221a020. J Med Chem. 1977. PMID: 915907

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