Singh SK - Search Results

1

Synthesis and biological evaluation of N alpha-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine.

Singh SK, Singer SC, Ferone R, Waters KA, Mullin RJ, Hynes JB. Singh SK, et al. J Med Chem. 1992 May 29;35(11):2002-6. doi: 10.1021/jm00089a009. J Med Chem. 1992. PMID: 1375963

2

Inhibition of hog liver folylpolyglutamate synthetase by 5-substituted 5,8-dideaza analogues of folic acid bearing a terminal L-ornithine residue.

Hynes JB, Singh SK, Fetzer O, Shane B. Hynes JB, et al. Among authors: singh sk. J Med Chem. 1992 Oct 30;35(22):4078-85. doi: 10.1021/jm00100a013. J Med Chem. 1992. PMID: 1433214

3

Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues.

Singh SK, Dev IK, Duch DS, Ferone R, Smith GK, Freisheim JH, Hynes JB. Singh SK, et al. J Med Chem. 1991 Feb;34(2):606-10. doi: 10.1021/jm00106a021. J Med Chem. 1991. PMID: 1995883

4

Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin bearing a terminal L-ornithine.

Patil SA, Shane B, Freisheim JH, Singh SK, Hynes JB. Patil SA, et al. Among authors: singh sk. J Med Chem. 1989 Jul;32(7):1559-65. doi: 10.1021/jm00127a026. J Med Chem. 1989. PMID: 2738891

5

Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity.

Jain M, Vangapandu S, Sachdeva S, Singh S, Singh PP, Jena GB, Tikoo K, Ramarao P, Kaul CL, Jain R. Jain M, et al. J Med Chem. 2004 Jan 15;47(2):285-7. doi: 10.1021/jm0304562. J Med Chem. 2004. PMID: 14711300

6

Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities.

Kaur K, Jain M, Khan SI, Jacob MR, Tekwani BL, Singh S, Singh PP, Jain R. Kaur K, et al. Eur J Med Chem. 2012 Jun;52:230-41. doi: 10.1016/j.ejmech.2012.03.019. Epub 2012 Mar 21. Eur J Med Chem. 2012. PMID: 22483965

7

8-quinolinamines and their pro prodrug conjugates as potent blood-schizontocidal antimalarial agents.

Vangapandu S, Sachdeva S, Jain M, Singh S, Singh PP, Kaul CL, Jain R. Vangapandu S, et al. Bioorg Med Chem. 2003 Oct 15;11(21):4557-68. doi: 10.1016/j.bmc.2003.07.003. Bioorg Med Chem. 2003. PMID: 14527552

8

Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines).

Kaur K, Jain M, Khan SI, Jacob MR, Tekwani BL, Singh S, Singh PP, Jain R. Kaur K, et al. Bioorg Med Chem. 2011 Jan 1;19(1):197-210. doi: 10.1016/j.bmc.2010.11.036. Epub 2010 Nov 25. Bioorg Med Chem. 2011. PMID: 21172735 Free PMC article.

9

Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues.

Jain M, Khan SI, Tekwani BL, Jacob MR, Singh S, Singh PP, Jain R. Jain M, et al. Bioorg Med Chem. 2005 Jul 15;13(14):4458-66. doi: 10.1016/j.bmc.2005.04.034. Bioorg Med Chem. 2005. PMID: 15878667

10

Guanylthiourea derivatives as potential antimalarial agents: Synthesis, in vivo and molecular modelling studies.

Bhagat S, Arfeen M, Adane L, Singh S, Singh PP, Chakraborti AK, Bharatam PV. Bhagat S, et al. Eur J Med Chem. 2017 Jul 28;135:339-348. doi: 10.1016/j.ejmech.2017.04.022. Epub 2017 Apr 21. Eur J Med Chem. 2017. PMID: 28460309

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