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An active-site mutation (Gly633-->Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum.
Tsuji E, Misumi Y, Fujiwara T, Takami N, Ogata S, Ikehara Y. Tsuji E, et al. Among authors: takami n. Biochemistry. 1992 Dec 1;31(47):11921-7. doi: 10.1021/bi00162a035. Biochemistry. 1992. PMID: 1359907
Cloning and sequencing of DPPIV cDNAs revealed a G to A transition at nucleotide 1897 in the cDNA sequence of 344/CRJ, which leads to substitution of Gly633-->Arg in the active-site sequence Gly629-Trp-Ser-Tyr-Gly633 determined for the wild-type DPPIV [Ogata, S., Misumi, Y., …
Cloning and sequencing of DPPIV cDNAs revealed a G to A transition at nucleotide 1897 in the cDNA sequence of 344/CRJ, which leads to substi …
66 results