Structure of a ricin mutant showing rescue of activity by a noncatalytic residue.
Kim Y, Mlsna D, Monzingo AF, Ready MP, Frankel A, Robertus JD.
Kim Y, et al. Among authors: frankel a.
Biochemistry. 1992 Mar 31;31(12):3294-6. doi: 10.1021/bi00127a035.
Biochemistry. 1992.
PMID: 1348187
Ricin A chain is an N-glycosidase which removes a single adenine base from a conservative loop of 28S rRNA, thereby inactivating eukaryotic ribosomes. ...D. (1991) Proteins: Struct., Funct., Genet. 10, 270-278] while conversion to Ala (E177A) reduces activity …
Ricin A chain is an N-glycosidase which removes a single adenine base from a conservative loop of 28S rRNA, thereby ina …