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Cytokine induction by purified lipoteichoic acids from various bacterial species--role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release.
Hermann C, Spreitzer I, Schröder NW, Morath S, Lehner MD, Fischer W, Schütt C, Schumann RR, Hartung T. Hermann C, et al. Among authors: schumann rr. Eur J Immunol. 2002 Feb;32(2):541-51. doi: 10.1002/1521-4141(200202)32:2<541::AID-IMMU541>3.0.CO;2-P. Eur J Immunol. 2002. PMID: 11828371 Free article.
Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.
Schröder NW, Morath S, Alexander C, Hamann L, Hartung T, Zähringer U, Göbel UB, Weber JR, Schumann RR. Schröder NW, et al. Among authors: schumann rr. J Biol Chem. 2003 May 2;278(18):15587-94. doi: 10.1074/jbc.M212829200. Epub 2003 Feb 19. J Biol Chem. 2003. PMID: 12594207 Free article.
Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.
Schröder NW, Diterich I, Zinke A, Eckert J, Draing C, von Baehr V, Hassler D, Priem S, Hahn K, Michelsen KS, Hartung T, Burmester GR, Göbel UB, Hermann C, Schumann RR. Schröder NW, et al. Among authors: schumann rr. J Immunol. 2005 Aug 15;175(4):2534-40. doi: 10.4049/jimmunol.175.4.2534. J Immunol. 2005. PMID: 16081826
The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2.
Michelsen KS, Aicher A, Mohaupt M, Hartung T, Dimmeler S, Kirschning CJ, Schumann RR. Michelsen KS, et al. Among authors: schumann rr. J Biol Chem. 2001 Jul 13;276(28):25680-6. doi: 10.1074/jbc.M011615200. Epub 2001 Apr 20. J Biol Chem. 2001. PMID: 11316801 Free article.
164 results