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Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.
Burrows SR, Chen Z, Archbold JK, Tynan FE, Beddoe T, Kjer-Nielsen L, Miles JJ, Khanna R, Moss DJ, Liu YC, Gras S, Kostenko L, Brennan RM, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J. Burrows SR, et al. Among authors: tynan fe. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10608-13. doi: 10.1073/pnas.1004926107. Epub 2010 May 18. Proc Natl Acad Sci U S A. 2010. PMID: 20483993 Free PMC article.
High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance.
Tynan FE, Borg NA, Miles JJ, Beddoe T, El-Hassen D, Silins SL, van Zuylen WJ, Purcell AW, Kjer-Nielsen L, McCluskey J, Burrows SR, Rossjohn J. Tynan FE, et al. J Biol Chem. 2005 Jun 24;280(25):23900-9. doi: 10.1074/jbc.M503060200. Epub 2005 Apr 22. J Biol Chem. 2005. PMID: 15849183 Free article.
T cell allorecognition via molecular mimicry.
Macdonald WA, Chen Z, Gras S, Archbold JK, Tynan FE, Clements CS, Bharadwaj M, Kjer-Nielsen L, Saunders PM, Wilce MC, Crawford F, Stadinsky B, Jackson D, Brooks AG, Purcell AW, Kappler JW, Burrows SR, Rossjohn J, McCluskey J. Macdonald WA, et al. Among authors: tynan fe. Immunity. 2009 Dec 18;31(6):897-908. doi: 10.1016/j.immuni.2009.09.025. Immunity. 2009. PMID: 20064448 Free article.
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