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The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.
Cota D, Marsicano G, Tschöp M, Grübler Y, Flachskamm C, Schubert M, Auer D, Yassouridis A, Thöne-Reineke C, Ortmann S, Tomassoni F, Cervino C, Nisoli E, Linthorst AC, Pasquali R, Lutz B, Stalla GK, Pagotto U. Cota D, et al. Among authors: tschop m. J Clin Invest. 2003 Aug;112(3):423-31. doi: 10.1172/JCI17725. J Clin Invest. 2003. PMID: 12897210 Free PMC article.
Ghrelin as a potential anti-obesity target.
Horvath TL, Castañeda T, Tang-Christensen M, Pagotto U, Tschöp MH. Horvath TL, et al. Among authors: tschop mh. Curr Pharm Des. 2003;9(17):1383-95. doi: 10.2174/1381612033454748. Curr Pharm Des. 2003. PMID: 12769730 Review.
Testosterone replacement therapy restores normal ghrelin in hypogonadal men.
Pagotto U, Gambineri A, Pelusi C, Genghini S, Cacciari M, Otto B, Castañeda T, Tschöp M, Pasquali R. Pagotto U, et al. Among authors: tschop m. J Clin Endocrinol Metab. 2003 Sep;88(9):4139-43. doi: 10.1210/jc.2003-030554. J Clin Endocrinol Metab. 2003. PMID: 12970277 Clinical Trial.
The central melanocortin system directly controls peripheral lipid metabolism.
Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH. Nogueiras R, et al. Among authors: tschop mh. J Clin Invest. 2007 Nov;117(11):3475-88. doi: 10.1172/JCI31743. J Clin Invest. 2007. PMID: 17885689 Free PMC article.
p62 links β-adrenergic input to mitochondrial function and thermogenesis.
Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH. Müller TD, et al. Among authors: tschop mh. J Clin Invest. 2013 Jan;123(1):469-78. doi: 10.1172/JCI64209. Epub 2012 Dec 21. J Clin Invest. 2013. PMID: 23257354 Free PMC article.
462 results