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Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa.
Renau TE, Léger R, Filonova L, Flamme EM, Wang M, Yen R, Madsen D, Griffith D, Chamberland S, Dudley MN, Lee VJ, Lomovskaya O, Watkins WJ, Ohta T, Nakayama K, Ishida Y. Renau TE, et al. Among authors: ohta t. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2755-8. doi: 10.1016/s0960-894x(03)00556-0. Bioorg Med Chem Lett. 2003. PMID: 12873508
MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: discovery and early strategies for lead optimization.
Nakayama K, Ishida Y, Ohtsuka M, Kawato H, Yoshida Ki, Yokomizo Y, Hosono S, Ohta T, Hoshino K, Ishida H, Yoshida K, Renau TE, Léger R, Zhang JZ, Lee VJ, Watkins WJ. Nakayama K, et al. Among authors: ohta t. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4201-4. doi: 10.1016/j.bmcl.2003.07.024. Bioorg Med Chem Lett. 2003. PMID: 14623001
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds.
Nakayama K, Ishida Y, Ohtsuka M, Kawato H, Yoshida K, Yokomizo Y, Ohta T, Hoshino K, Otani T, Kurosaka Y, Yoshida K, Ishida H, Lee VJ, Renau TE, Watkins WJ. Nakayama K, et al. Among authors: ohta t. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4205-8. doi: 10.1016/j.bmcl.2003.07.027. Bioorg Med Chem Lett. 2003. PMID: 14623002
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model.
Nakayama K, Kawato H, Watanabe J, Ohtsuka M, Yoshida K, Yokomizo Y, Sakamoto A, Kuru N, Ohta T, Hoshino K, Yoshida K, Ishida H, Cho A, Palme MH, Zhang JZ, Lee VJ, Watkins WJ. Nakayama K, et al. Among authors: ohta t. Bioorg Med Chem Lett. 2004 Jan 19;14(2):475-9. doi: 10.1016/j.bmcl.2003.10.060. Bioorg Med Chem Lett. 2004. PMID: 14698185
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety.
Nakayama K, Kuru N, Ohtsuka M, Yokomizo Y, Sakamoto A, Kawato H, Yoshida K, Ohta T, Hoshino K, Akimoto K, Itoh J, Ishida H, Cho A, Palme MH, Zhang JZ, Lee VJ, Watkins WJ. Nakayama K, et al. Among authors: ohta t. Bioorg Med Chem Lett. 2004 May 17;14(10):2493-7. doi: 10.1016/j.bmcl.2004.03.007. Bioorg Med Chem Lett. 2004. PMID: 15109639
3,630 results