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A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.
Turella P, Filomeni G, Dupuis ML, Ciriolo MR, Molinari A, De Maria F, Tombesi M, Cianfriglia M, Federici G, Ricci G, Caccuri AM. Turella P, et al. Among authors: federici g. J Biol Chem. 2006 Aug 18;281(33):23725-32. doi: 10.1074/jbc.M604372200. Epub 2006 Jun 12. J Biol Chem. 2006. PMID: 16769721 Free article.
Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope.
Stella L, Pallottini V, Moreno S, Leoni S, De Maria F, Turella P, Federici G, Fabrini R, Dawood KF, Bello ML, Pedersen JZ, Ricci G. Stella L, et al. Among authors: federici g. J Biol Chem. 2007 Mar 2;282(9):6372-9. doi: 10.1074/jbc.M609906200. Epub 2006 Dec 30. J Biol Chem. 2007. PMID: 17197701 Free article.
The discovery that the dinitrosyl-diglutathionyl-iron complex binds tightly to Alpha class GSTs in rat hepatocytes and that a significant part of the bound complex is also associated with the nuclear fraction (Pedersen, J. Z., De Maria, F., Turella, P., Federici, G. …
The discovery that the dinitrosyl-diglutathionyl-iron complex binds tightly to Alpha class GSTs in rat hepatocytes and that a significant pa …
Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells. A protection mechanism against excess nitric oxide.
Pedersen JZ, De Maria F, Turella P, Federici G, Mattei M, Fabrini R, Dawood KF, Massimi M, Caccuri AM, Ricci G. Pedersen JZ, et al. Among authors: federici g. J Biol Chem. 2007 Mar 2;282(9):6364-71. doi: 10.1074/jbc.M609905200. Epub 2006 Dec 30. J Biol Chem. 2007. PMID: 17197702 Free article.
Surprisingly, about 20% of the dinitrosyl-glutathionyl-iron complex-GST is found to be associated with subcellular components, mainly the nucleus, as demonstrated in the accompanying paper (Stella, L., Pallottini, V., Moreno, S., Leoni, S., De Maria, F., Turella, P., Federici …
Surprisingly, about 20% of the dinitrosyl-glutathionyl-iron complex-GST is found to be associated with subcellular components, mainly the nu …
The extended catalysis of glutathione transferase.
Fabrini R, Bocedi A, Dawood KF, Turella P, Stella L, Parker MW, Pedersen JZ, Federici G, Antonini G, Ricci G. Fabrini R, et al. Among authors: federici g. FEBS Lett. 2011 Jan 21;585(2):341-5. doi: 10.1016/j.febslet.2010.12.009. Epub 2010 Dec 14. FEBS Lett. 2011. PMID: 21163259 Free article.
The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force.
Bocedi A, Fabrini R, Farrotti A, Stella L, Ketterman AJ, Pedersen JZ, Allocati N, Lau PC, Grosse S, Eltis LD, Ruzzini A, Edwards TE, Morici L, Del Grosso E, Guidoni L, Bovi D, Lo Bello M, Federici G, Parker MW, Board PG, Ricci G. Bocedi A, et al. Among authors: federici g. J Biol Chem. 2013 Aug 23;288(34):24936-47. doi: 10.1074/jbc.M113.476135. Epub 2013 Jul 3. J Biol Chem. 2013. PMID: 23828197 Free PMC article.
416 results