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The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide.
De Maria F, Pedersen JZ, Caccuri AM, Antonini G, Turella P, Stella L, Lo Bello M, Federici G, Ricci G. De Maria F, et al. J Biol Chem. 2003 Oct 24;278(43):42283-93. doi: 10.1074/jbc.M305568200. Epub 2003 Jul 18. J Biol Chem. 2003. PMID: 12871945 Free article.
Binding and kinetic mechanisms of the Zeta class glutathione transferase.
Ricci G, Turella P, De Maria F, Antonini G, Nardocci L, Board PG, Parker MW, Carbonelli MG, Federici G, Caccuri AM. Ricci G, et al. Among authors: de maria f. J Biol Chem. 2004 Aug 6;279(32):33336-42. doi: 10.1074/jbc.M404631200. Epub 2004 Jun 1. J Biol Chem. 2004. PMID: 15173170 Free article.
Proapoptotic activity of new glutathione S-transferase inhibitors.
Turella P, Cerella C, Filomeni G, Bullo A, De Maria F, Ghibelli L, Ciriolo MR, Cianfriglia M, Mattei M, Federici G, Ricci G, Caccuri AM. Turella P, et al. Among authors: de maria f. Cancer Res. 2005 May 1;65(9):3751-61. doi: 10.1158/0008-5472.CAN-04-3903. Cancer Res. 2005. PMID: 15867371 Free article.
7-Nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases. Mechanism of action of potential anticancer drugs.
Ricci G, De Maria F, Antonini G, Turella P, Bullo A, Stella L, Filomeni G, Federici G, Caccuri AM. Ricci G, et al. Among authors: de maria f. J Biol Chem. 2005 Jul 15;280(28):26397-405. doi: 10.1074/jbc.M503295200. Epub 2005 May 11. J Biol Chem. 2005. PMID: 15888444 Free article.
We have recently shown that submicromolar amounts of NBDHEX trigger apoptosis in several human tumor cell lines through the dissociation of the JNK.GSTP1-1 complex (Turella, P., Cerella, C., Filomeni, G., Bullo, A., De Maria, F., Ghibelli, L., Ciriolo, M. R., …
We have recently shown that submicromolar amounts of NBDHEX trigger apoptosis in several human tumor cell lines through the dissociation of …
A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.
Turella P, Filomeni G, Dupuis ML, Ciriolo MR, Molinari A, De Maria F, Tombesi M, Cianfriglia M, Federici G, Ricci G, Caccuri AM. Turella P, et al. Among authors: de maria f. J Biol Chem. 2006 Aug 18;281(33):23725-32. doi: 10.1074/jbc.M604372200. Epub 2006 Jun 12. J Biol Chem. 2006. PMID: 16769721 Free article.
Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope.
Stella L, Pallottini V, Moreno S, Leoni S, De Maria F, Turella P, Federici G, Fabrini R, Dawood KF, Bello ML, Pedersen JZ, Ricci G. Stella L, et al. Among authors: de maria f. J Biol Chem. 2007 Mar 2;282(9):6372-9. doi: 10.1074/jbc.M609906200. Epub 2006 Dec 30. J Biol Chem. 2007. PMID: 17197701 Free article.
The discovery that the dinitrosyl-diglutathionyl-iron complex binds tightly to Alpha class GSTs in rat hepatocytes and that a significant part of the bound complex is also associated with the nuclear fraction (Pedersen, J. Z., De Maria, F., Turella, P., Feder …
The discovery that the dinitrosyl-diglutathionyl-iron complex binds tightly to Alpha class GSTs in rat hepatocytes and that a significant pa …
Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells. A protection mechanism against excess nitric oxide.
Pedersen JZ, De Maria F, Turella P, Federici G, Mattei M, Fabrini R, Dawood KF, Massimi M, Caccuri AM, Ricci G. Pedersen JZ, et al. Among authors: de maria f. J Biol Chem. 2007 Mar 2;282(9):6364-71. doi: 10.1074/jbc.M609905200. Epub 2006 Dec 30. J Biol Chem. 2007. PMID: 17197702 Free article.
Surprisingly, about 20% of the dinitrosyl-glutathionyl-iron complex-GST is found to be associated with subcellular components, mainly the nucleus, as demonstrated in the accompanying paper (Stella, L., Pallottini, V., Moreno, S., Leoni, S., De Maria, F., Ture …
Surprisingly, about 20% of the dinitrosyl-glutathionyl-iron complex-GST is found to be associated with subcellular components, mainly the nu …
64 results