McMahon G - Search Results

1

Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies.

London CA, Hannah AL, Zadovoskaya R, Chien MB, Kollias-Baker C, Rosenberg M, Downing S, Post G, Boucher J, Shenoy N, Mendel DB, McMahon G, Cherrington JM. London CA, et al. Among authors: mcmahon g. Clin Cancer Res. 2003 Jul;9(7):2755-68. Clin Cancer Res. 2003. PMID: 12855656 Clinical Trial.

2

Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors.

Liao AT, Chien MB, Shenoy N, Mendel DB, McMahon G, Cherrington JM, London CA. Liao AT, et al. Among authors: mcmahon g. Blood. 2002 Jul 15;100(2):585-93. doi: 10.1182/blood-2001-12-0350. Blood. 2002. PMID: 12091352 Free article.

3

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM. Mendel DB, et al. Among authors: mcmahon g. Clin Cancer Res. 2003 Jan;9(1):327-37. Clin Cancer Res. 2003. PMID: 12538485

4

KTN0158, a Humanized Anti-KIT Monoclonal Antibody, Demonstrates Biologic Activity against both Normal and Malignant Canine Mast Cells.

London CA, Gardner HL, Rippy S, Post G, La Perle K, Crew L, Lopresti-Morrow L, Garton AJ, McMahon G, LaVallee TM, Gedrich R. London CA, et al. Among authors: mcmahon g. Clin Cancer Res. 2017 May 15;23(10):2565-2574. doi: 10.1158/1078-0432.CCR-16-2152. Epub 2016 Nov 4. Clin Cancer Res. 2017. PMID: 27815356 Free PMC article.

5

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

Laird AD, Vajkoczy P, Shawver LK, Thurnher A, Liang C, Mohammadi M, Schlessinger J, Ullrich A, Hubbard SR, Blake RA, Fong TA, Strawn LM, Sun L, Tang C, Hawtin R, Tang F, Shenoy N, Hirth KP, McMahon G, Cherrington. Laird AD, et al. Among authors: mcmahon g. Cancer Res. 2000 Aug 1;60(15):4152-60. Cancer Res. 2000. PMID: 10945623

6

SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models.

Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE. Schueneman AJ, et al. Among authors: mcmahon g. Cancer Res. 2003 Jul 15;63(14):4009-16. Cancer Res. 2003. PMID: 12873999

7

SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase.

Yee KW, O'Farrell AM, Smolich BD, Cherrington JM, McMahon G, Wait CL, McGreevey LS, Griffith DJ, Heinrich MC. Yee KW, et al. Among authors: mcmahon g. Blood. 2002 Oct 15;100(8):2941-9. doi: 10.1182/blood-2002-02-0531. Blood. 2002. PMID: 12351406 Free article.

8

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, Ullrich A, Hirth KP, McMahon G. Fong TA, et al. Among authors: mcmahon g. Cancer Res. 1999 Jan 1;59(1):99-106. Cancer Res. 1999. PMID: 9892193

9

Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling.

Itokawa T, Nokihara H, Nishioka Y, Sone S, Iwamoto Y, Yamada Y, Cherrington J, McMahon G, Shibuya M, Kuwano M, Ono M. Itokawa T, et al. Among authors: mcmahon g. Mol Cancer Ther. 2002 Mar;1(5):295-302. Mol Cancer Ther. 2002. PMID: 12489845

10

Flk-1 as a target for tumor growth inhibition.

Strawn LM, McMahon G, App H, Schreck R, Kuchler WR, Longhi MP, Hui TH, Tang C, Levitzki A, Gazit A, Chen I, Keri G, Orfi L, Risau W, Flamme I, Ullrich A, Hirth KP, Shawver LK. Strawn LM, et al. Among authors: mcmahon g. Cancer Res. 1996 Aug 1;56(15):3540-5. Cancer Res. 1996. PMID: 8758924

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