Boehrer S - Search Results

1

Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571.

Beissert T, Puccetti E, Bianchini A, Güller S, Boehrer S, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M. Beissert T, et al. Among authors: boehrer s. Blood. 2003 Oct 15;102(8):2985-93. doi: 10.1182/blood-2003-03-0811. Epub 2003 Jun 26. Blood. 2003. PMID: 12829585 Free article.

2

Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.

Zheng X, Beissert T, Kukoc-Zivojnov N, Puccetti E, Altschmied J, Strolz C, Boehrer S, Gul H, Schneider O, Ottmann OG, Hoelzer D, Henschler R, Ruthardt M. Zheng X, et al. Among authors: boehrer s. Blood. 2004 May 1;103(9):3535-43. doi: 10.1182/blood-2003-09-3335. Epub 2004 Jan 22. Blood. 2004. PMID: 14739224 Free article.

3

In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation.

Boehrer S, Chow KU, Beske F, Kukoc-Zivojnov N, Puccetti E, Ruthardt M, Baum C, Rangnekar VM, Hoelzer D, Mitrou PS, Weidmann E. Boehrer S, et al. Cancer Res. 2002 Mar 15;62(6):1768-75. Cancer Res. 2002. PMID: 11912153

4

AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.

Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M. Puccetti E, et al. Among authors: boehrer s. Cancer Res. 2002 Dec 1;62(23):7050-8. Cancer Res. 2002. PMID: 12460926

5

In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors.

Brieger A, Boehrer S, Schaaf S, Nowak D, Ruthardt M, Kim SZ, Atadja P, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. Brieger A, et al. Among authors: boehrer s. Biochem Pharmacol. 2004 Jul 1;68(1):85-93. doi: 10.1016/j.bcp.2004.02.028. Biochem Pharmacol. 2004. PMID: 15183120

6

Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells.

Kukoc-Zivojnov N, Puccetti E, Chow KU, Bergmann M, Ruthardt M, Hoelzer D, Mitrou PS, Weidmann E, Boehrer S. Kukoc-Zivojnov N, et al. Among authors: boehrer s. Exp Hematol. 2004 Jul;32(7):649-56. doi: 10.1016/j.exphem.2004.04.004. Exp Hematol. 2004. PMID: 15246161 Free article.

7

The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.

Puccetti E, Zheng X, Brambilla D, Seshire A, Beissert T, Boehrer S, Nürnberger H, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M. Puccetti E, et al. Among authors: boehrer s. Cancer Res. 2005 Jul 15;65(14):6080-8. doi: 10.1158/0008-5472.CAN-04-3631. Cancer Res. 2005. PMID: 16024608

8

Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis.

Boehrer S, Nowak D, Puccetti E, Ruthardt M, Sattler N, Trepohl B, Schneider B, Hoelzer D, Mitrou PS, Chow KU. Boehrer S, et al. Leuk Res. 2006 May;30(5):597-605. doi: 10.1016/j.leukres.2005.09.003. Epub 2006 Mar 2. Leuk Res. 2006. PMID: 16513168

9

The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines.

Chow KU, Nowak D, Trepohl B, Hochmuth S, Schneider B, Hoelzer D, Mitrou PS, Bergmann L, Ottmann OG, Boehrer S. Chow KU, et al. Among authors: boehrer s. Leuk Lymphoma. 2007 Jul;48(7):1379-88. doi: 10.1080/10428190701385181. Leuk Lymphoma. 2007. PMID: 17613767

10

Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells.

Nowak D, Boehrer S, Hochmuth S, Trepohl B, Hofmann W, Hoelzer D, Hofmann WK, Mitrou PS, Ruthardt M, Chow KU. Nowak D, et al. Among authors: boehrer s. Anticancer Drugs. 2007 Oct;18(9):981-95. doi: 10.1097/CAD.0b013e3281721ff6. Anticancer Drugs. 2007. PMID: 17704648

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