Bradford LD - Search Results

1

Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects.

Gaedigk A, Ndjountché L, Gaedigk R, Leeder JS, Bradford LD. Gaedigk A, et al. Among authors: bradford ld. Clin Pharmacol Ther. 2003 Jun;73(6):575-6. doi: 10.1016/S0009-9236(03)00067-5. Clin Pharmacol Ther. 2003. PMID: 12811367 No abstract available.

2

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.

Gaedigk A, Bradford LD, Marcucci KA, Leeder JS. Gaedigk A, et al. Among authors: bradford ld. Clin Pharmacol Ther. 2002 Jul;72(1):76-89. doi: 10.1067/mcp.2002.125783. Clin Pharmacol Ther. 2002. PMID: 12152006 Clinical Trial.

3

CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism.

Gaedigk A, Ryder DL, Bradford LD, Leeder JS. Gaedigk A, et al. Among authors: bradford ld. Clin Chem. 2003 Jun;49(6 Pt 1):1008-11. doi: 10.1373/49.6.1008. Clin Chem. 2003. PMID: 12766015 No abstract available.

4

Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects.

Gaedigk A, Ndjountché L, Leeder JS, Bradford LD. Gaedigk A, et al. Among authors: bradford ld. Clin Pharmacol Ther. 2005 Mar;77(3):228-30; author reply 230-1. doi: 10.1016/j.clpt.2004.10.014. Clin Pharmacol Ther. 2005. PMID: 15735618 No abstract available.

5

Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.

Gaedigk A, Eklund JD, Pearce RE, Leeder JS, Alander SW, Phillips MS, Bradford LD, Kennedy MJ. Gaedigk A, et al. Among authors: bradford ld. Clin Pharmacol Ther. 2007 Jun;81(6):817-20. doi: 10.1038/sj.clpt.6100125. Epub 2007 Mar 28. Clin Pharmacol Ther. 2007. PMID: 17392730

6

The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.

Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, Leeder JS. Gaedigk A, et al. Among authors: bradford ld. Clin Pharmacol Ther. 2008 Feb;83(2):234-42. doi: 10.1038/sj.clpt.6100406. Epub 2007 Oct 31. Clin Pharmacol Ther. 2008. PMID: 17971818

7

Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.

Gaedigk A, Bhathena A, Ndjountché L, Pearce RE, Abdel-Rahman SM, Alander SW, Bradford LD, Rogan PK, Leeder JS. Gaedigk A, et al. Among authors: bradford ld. Pharmacogenomics J. 2005;5(3):173-82. doi: 10.1038/sj.tpj.6500305. Pharmacogenomics J. 2005. PMID: 15768052 Free PMC article.

8

High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data.

Bradford LD, Gaedigk A, Leeder JS. Bradford LD, et al. Psychopharmacol Bull. 1998;34(4):797-804. Psychopharmacol Bull. 1998. PMID: 10513455 Review.

9

CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.

Gaedigk A, Bradford LD, Alander SW, Leeder JS. Gaedigk A, et al. Among authors: bradford ld. Drug Metab Dispos. 2006 Apr;34(4):563-9. doi: 10.1124/dmd.105.008292. Epub 2006 Jan 13. Drug Metab Dispos. 2006. PMID: 16415111

10

In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.

Ramamoorthy A, Li L, Gaedigk A, Bradford LD, Benson EA, Flockhart DA, Skaar TC. Ramamoorthy A, et al. Among authors: bradford ld. Drug Metab Dispos. 2012 Apr;40(4):726-33. doi: 10.1124/dmd.111.040329. Epub 2012 Jan 9. Drug Metab Dispos. 2012. PMID: 22232426 Free PMC article.

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