Hughes TE - Search Results

1

1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.

Villhauer EB, Brinkman JA, Naderi GB, Burkey BF, Dunning BE, Prasad K, Mangold BL, Russell ME, Hughes TE. Villhauer EB, et al. Among authors: hughes te. J Med Chem. 2003 Jun 19;46(13):2774-89. doi: 10.1021/jm030091l. J Med Chem. 2003. PMID: 12801240

2

1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.

Villhauer EB, Brinkman JA, Naderi GB, Dunning BE, Mangold BL, Mone MD, Russell ME, Weldon SC, Hughes TE. Villhauer EB, et al. Among authors: hughes te. J Med Chem. 2002 Jun 6;45(12):2362-5. doi: 10.1021/jm025522z. J Med Chem. 2002. PMID: 12036346

3

NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV.

Hughes TE, Mone MD, Russell ME, Weldon SC, Villhauer EB. Hughes TE, et al. Biochemistry. 1999 Sep 7;38(36):11597-603. doi: 10.1021/bi990852f. Biochemistry. 1999. PMID: 10512614

4

1-Aminomethylisoquinoline-4-carboxylates as novel dipeptidylpeptidase IV inhibitors.

Coppola GM, Zhang YL, Schuster HF, Russell ME, Hughes TE. Coppola GM, et al. Among authors: hughes te. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1555-8. doi: 10.1016/s0960-894x(00)00286-9. Bioorg Med Chem Lett. 2000. PMID: 10915049

5

The DPP-4 inhibitor vildagliptin increases pancreatic beta cell mass in neonatal rats.

Duttaroy A, Voelker F, Merriam K, Zhang X, Ren X, Subramanian K, Hughes TE, Burkey BF. Duttaroy A, et al. Among authors: hughes te. Eur J Pharmacol. 2011 Jan 15;650(2-3):703-7. doi: 10.1016/j.ejphar.2010.10.062. Epub 2010 Nov 9. Eur J Pharmacol. 2011. PMID: 21070766

6

Acute and chronic effects of the incretin enhancer vildagliptin in insulin-resistant rats.

Burkey BF, Li X, Bolognese L, Balkan B, Mone M, Russell M, Hughes TE, Wang PR. Burkey BF, et al. Among authors: hughes te. J Pharmacol Exp Ther. 2005 Nov;315(2):688-95. doi: 10.1124/jpet.105.087064. Epub 2005 Jul 18. J Pharmacol Exp Ther. 2005. PMID: 16027230

7

Beta-cell expression of a dominant-negative HNF-1alpha compromises the ability of inhibition of dipeptidyl peptidase-4 to elicit a long-term augmentation of insulin secretion in mice.

Ahrén B, Sörhede Winzell M, Burkey B, Hughes TE. Ahrén B, et al. Among authors: hughes te. Eur J Pharmacol. 2005 Oct 3;521(1-3):164-8. doi: 10.1016/j.ejphar.2005.08.019. Epub 2005 Sep 19. Eur J Pharmacol. 2005. PMID: 16171801

8

DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.

Ahrén B, Winzell MS, Wierup N, Sundler F, Burkey B, Hughes TE. Ahrén B, et al. Among authors: hughes te. Regul Pept. 2007 Oct 4;143(1-3):97-103. doi: 10.1016/j.regpep.2007.03.008. Epub 2007 Apr 11. Regul Pept. 2007. PMID: 17482289

9

Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061.

Burkey BF, Hoglen NC, Inskeep P, Wyman M, Hughes TE, Vath JE. Burkey BF, et al. Among authors: hughes te. J Pharmacol Exp Ther. 2018 May;365(2):301-313. doi: 10.1124/jpet.117.246272. Epub 2018 Feb 28. J Pharmacol Exp Ther. 2018. PMID: 29491038

10

Dipeptidyl peptidase IV inhibition improves impaired glucose tolerance in high-fat diet-fed rats: study using a Fischer 344 rat substrain deficient in its enzyme activity.

Mitani H, Takimoto M, Hughes TE, Kimura M. Mitani H, et al. Among authors: hughes te. Jpn J Pharmacol. 2002 Apr;88(4):442-50. doi: 10.1254/jjp.88.442. Jpn J Pharmacol. 2002. PMID: 12046988 Free article.

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