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Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance.
Chakraborty JB, Mahato SK, Joshi K, Shinde V, Rakshit S, Biswas N, Choudhury Mukherjee I, Mandal L, Ganguly D, Chowdhury AA, Chaudhuri J, Paul K, Pal BC, Vinayagam J, Pal C, Manna A, Jaisankar P, Chaudhuri U, Konar A, Roy S, Bandyopadhyay S. Chakraborty JB, et al. Among authors: choudhury mukherjee i. Cancer Sci. 2012 Jan;103(1):88-99. doi: 10.1111/j.1349-7006.2011.02107.x. Epub 2011 Nov 7. Cancer Sci. 2012. PMID: 21943109 Free PMC article.