Lewin NE - Search Results

1

Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones.

Kang JH, Chung HE, Kim SY, Kim Y, Lee J, Lewin NE, Pearce LV, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: lewin ne. Bioorg Med Chem. 2003 Jun 12;11(12):2529-39. doi: 10.1016/s0968-0896(03)00156-1. Bioorg Med Chem. 2003. PMID: 12757721

2

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Sigano DM, et al. Among authors: lewin ne. J Med Chem. 2003 Apr 24;46(9):1571-9. doi: 10.1021/jm020476o. J Med Chem. 2003. PMID: 12699375

3

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.

Choi Y, Kang JH, Lewin NE, Blumberg PM, Lee J, Marquez VE. Choi Y, et al. Among authors: lewin ne. J Med Chem. 2003 Jun 19;46(13):2790-3. doi: 10.1021/jm030082c. J Med Chem. 2003. PMID: 12801241

4

Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones.

Tamamura H, Sigano DM, Lewin NE, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: lewin ne. J Med Chem. 2004 Jan 29;47(3):644-55. doi: 10.1021/jm030454h. J Med Chem. 2004. PMID: 14736244

5

Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands.

Duan D, Lewin NE, Sigano DM, Blumberg PM, Marquez VE. Duan D, et al. Among authors: lewin ne. J Med Chem. 2004 Jun 3;47(12):3248-54. doi: 10.1021/jm030610k. J Med Chem. 2004. PMID: 15163204

6

Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones.

Kang JH, Siddiqui MA, Sigano DM, Krajewski K, Lewin NE, Pu Y, Blumberg PM, Lee J, Marquez VE. Kang JH, et al. Among authors: lewin ne. Org Lett. 2004 Jul 8;6(14):2413-6. doi: 10.1021/ol0492041. Org Lett. 2004. PMID: 15228292

7

Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. Interactions with protein kinase C.

Kang JH, Kim SY, Lee J, Marquez VE, Lewin NE, Pearce LV, Blumberg PM. Kang JH, et al. Among authors: lewin ne. J Med Chem. 2004 Jul 29;47(16):4000-7. doi: 10.1021/jm0497747. J Med Chem. 2004. PMID: 15267238

8

Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).

Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: lewin ne. J Med Chem. 2004 Sep 23;47(20):4858-64. doi: 10.1021/jm049723+. J Med Chem. 2004. PMID: 15369389

9

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.

Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: lewin ne. J Med Chem. 2005 Sep 8;48(18):5738-48. doi: 10.1021/jm050352m. J Med Chem. 2005. PMID: 16134942 Free PMC article.

10

2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands.

Lee J, Lee JH, Kim SY, Perry NA, Lewin NE, Ayres JA, Blumberg PM. Lee J, et al. Among authors: lewin ne. Bioorg Med Chem. 2006 Mar 15;14(6):2022-31. doi: 10.1016/j.bmc.2005.10.051. Epub 2005 Nov 15. Bioorg Med Chem. 2006. PMID: 16297629

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