Hobbs AJ - Search Results

1

Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression.

Connelly L, Jacobs AT, Palacios-Callender M, Moncada S, Hobbs AJ. Connelly L, et al. Among authors: hobbs aj. J Biol Chem. 2003 Jul 18;278(29):26480-7. doi: 10.1074/jbc.M302238200. Epub 2003 May 9. J Biol Chem. 2003. PMID: 12740377 Free article.

2

Inhibition of nitric oxide synthase as a potential therapeutic target.

Hobbs AJ, Higgs A, Moncada S. Hobbs AJ, et al. Annu Rev Pharmacol Toxicol. 1999;39:191-220. doi: 10.1146/annurev.pharmtox.39.1.191. Annu Rev Pharmacol Toxicol. 1999. PMID: 10331082 Review.

3

Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity.

Wolzt M, MacAllister RJ, Davis D, Feelisch M, Moncada S, Vallance P, Hobbs AJ. Wolzt M, et al. Among authors: hobbs aj. J Biol Chem. 1999 Oct 8;274(41):28983-90. doi: 10.1074/jbc.274.41.28983. J Biol Chem. 1999. PMID: 10506146 Free article.

4

Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase.

Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC, Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G, Woo CK. Selwood DL, et al. Among authors: hobbs aj. J Med Chem. 2001 Jan 4;44(1):78-93. doi: 10.1021/jm001034k. J Med Chem. 2001. PMID: 11141091

5

Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide.

Connelly L, Palacios-Callender M, Ameixa C, Moncada S, Hobbs AJ. Connelly L, et al. Among authors: hobbs aj. J Immunol. 2001 Mar 15;166(6):3873-81. doi: 10.4049/jimmunol.166.6.3873. J Immunol. 2001. PMID: 11238631

6

BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.

Kalsi JS, Rees RW, Hobbs AJ, Royle M, Kell PD, Ralph DJ, Moncada S, Cellek S. Kalsi JS, et al. Among authors: hobbs aj. J Urol. 2003 Feb;169(2):761-6. doi: 10.1097/01.ju.0000043880.58140.69. J Urol. 2003. PMID: 12544359

7

Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272.

Hobbs AJ, Moncada S. Hobbs AJ, et al. Vascul Pharmacol. 2003 Oct;40(3):149-54. doi: 10.1016/s1537-1891(03)00046-6. Vascul Pharmacol. 2003. PMID: 13678646

8

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.

Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ. Ahluwalia A, et al. Among authors: hobbs aj. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1386-91. doi: 10.1073/pnas.0304264101. Epub 2004 Jan 23. Proc Natl Acad Sci U S A. 2004. PMID: 14742866 Free PMC article.

9

Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo.

Connelly L, Madhani M, Hobbs AJ. Connelly L, et al. Among authors: hobbs aj. J Biol Chem. 2005 Mar 18;280(11):10040-6. doi: 10.1074/jbc.M411991200. Epub 2005 Jan 12. J Biol Chem. 2005. PMID: 15647265 Free article.

10

Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.

Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ, Ahluwalia A. Scotland RS, et al. Among authors: hobbs aj. Circulation. 2005 Feb 15;111(6):796-803. doi: 10.1161/01.CIR.0000155238.70797.4E. Epub 2005 Feb 7. Circulation. 2005. PMID: 15699263

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