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Gefitinib inhibits the growth and invasion of urothelial carcinoma cell lines in which Akt and MAPK activation is dependent on constitutive epidermal growth factor receptor activation.
Nicolle G, Daher A, Maillé P, Vermey M, Loric S, Bakkar A, Wallerand H, Vordos D, Vacherot F, de Medina SG, Abbou CC, Van der Kwast T, Thiery JP, Radvanyi F, Chopin DK. Nicolle G, et al. Among authors: de medina sg. Clin Cancer Res. 2006 May 1;12(9):2937-43. doi: 10.1158/1078-0432.CCR-05-2148. Clin Cancer Res. 2006. PMID: 16675591
Occupational exposure to polycyclic aromatic hydrocarbons influenced neither the frequency nor the spectrum of FGFR3 mutations in bladder urothelial carcinoma.
Bakkar AA, Allory Y, Iwatsubo Y, de Medina SG, Maille P, Khreich N, Riou A, Leroy K, Vordos D, Abbou CC, Andujar P, Billebaud T, Chammings S, Conso F, De La Taille A, Fontaine E, Gattegno B, Ravery V, Sibony M, Radvanyi F, Chopin DK, Pairon JC. Bakkar AA, et al. Among authors: de medina sg. Mol Carcinog. 2010 Jan;49(1):25-31. doi: 10.1002/mc.20573. Mol Carcinog. 2010. PMID: 19722178
Sensitive allele-specific PCR assay able to detect FGFR3 mutations in tumors and urine from patients with urothelial cell carcinoma of the bladder.
Bakkar AA, Quach V, Le Borgne A, Toublanc M, Henin D, Wallerand H, Radvanyi F, Bittard H, Ravery V, Gibod LB, de Medina SG, Chopin DK, Grandchamp B. Bakkar AA, et al. Among authors: de medina sg. Clin Chem. 2005 Aug;51(8):1555-7. doi: 10.1373/clinchem.2005.049619. Clin Chem. 2005. PMID: 16040860 No abstract available.
Mutations in TP53, but not FGFR3, in urothelial cell carcinoma of the bladder are influenced by smoking: contribution of exogenous versus endogenous carcinogens.
Wallerand H, Bakkar AA, de Medina SG, Pairon JC, Yang YC, Vordos D, Bittard H, Fauconnet S, Kouyoumdjian JC, Jaurand MC, Zhang ZF, Radvanyi F, Thiery JP, Chopin DK. Wallerand H, et al. Among authors: de medina sg. Carcinogenesis. 2005 Jan;26(1):177-84. doi: 10.1093/carcin/bgh275. Epub 2004 Sep 3. Carcinogenesis. 2005. PMID: 15347601
Regional copy number-independent deregulation of transcription in cancer.
Stransky N, Vallot C, Reyal F, Bernard-Pierrot I, de Medina SG, Segraves R, de Rycke Y, Elvin P, Cassidy A, Spraggon C, Graham A, Southgate J, Asselain B, Allory Y, Abbou CC, Albertson DG, Thiery JP, Chopin DK, Pinkel D, Radvanyi F. Stransky N, et al. Among authors: de medina sg. Nat Genet. 2006 Dec;38(12):1386-96. doi: 10.1038/ng1923. Epub 2006 Nov 12. Nat Genet. 2006. PMID: 17099711
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