Wu G - Search Results

1

N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.

Valenzano KJ, Grant ER, Wu G, Hachicha M, Schmid L, Tafesse L, Sun Q, Rotshteyn Y, Francis J, Limberis J, Malik S, Whittemore ER, Hodges D. Valenzano KJ, et al. Among authors: wu g. J Pharmacol Exp Ther. 2003 Jul;306(1):377-86. doi: 10.1124/jpet.102.045674. Epub 2003 Apr 29. J Pharmacol Exp Ther. 2003. PMID: 12721338

2

Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management.

Tafesse L, Kanemasa T, Kurose N, Yu J, Asaki T, Wu G, Iwamoto Y, Yamaguchi Y, Ni C, Engel J, Tsuno N, Patel A, Zhou X, Shintani T, Brown K, Hasegawa T, Shet M, Iso Y, Kato A, Kyle DJ. Tafesse L, et al. Among authors: wu g. J Med Chem. 2014 Aug 14;57(15):6781-94. doi: 10.1021/jm500818a. Epub 2014 Aug 1. J Med Chem. 2014. PMID: 25057800

3

A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats.

Wu G, Whiteside GT, Lee G, Nolan S, Niosi M, Pearson MS, Ilyin VI. Wu G, et al. Eur J Pharmacol. 2004 Nov 3;504(1-2):45-53. doi: 10.1016/j.ejphar.2004.09.056. Eur J Pharmacol. 2004. PMID: 15507220

4

Phenylarsine oxide as a redox modulator of transient receptor potential vanilloid type 1 channel function.

Carlin KP, Wu G, Patel A, Crumley G, Ilyin VI. Carlin KP, et al. Among authors: wu g. J Neurosci Res. 2015 Feb;93(2):309-20. doi: 10.1002/jnr.23479. Epub 2014 Sep 24. J Neurosci Res. 2015. PMID: 25250537

5

Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.

Park JH, Carlin KP, Wu G, Ilyin VI, Musza LL, Blake PR, Kyle DJ. Park JH, et al. Among authors: wu g. J Med Chem. 2014 Aug 14;57(15):6623-31. doi: 10.1021/jm500687u. Epub 2014 Jul 24. J Med Chem. 2014. PMID: 25026046

6

Discovery of thieno[3,2-c]pyridin-4-amines as novel Bruton's tyrosine kinase (BTK) inhibitors.

Zhao X, Xin M, Wang Y, Huang W, Jin Q, Tang F, Wu G, Zhao Y, Xiang H. Zhao X, et al. Among authors: wu g. Bioorg Med Chem. 2015 Sep 1;23(17):6059-68. doi: 10.1016/j.bmc.2015.05.043. Epub 2015 May 31. Bioorg Med Chem. 2015. PMID: 26277759

7

Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide--protoxin II.

Park JH, Carlin KP, Wu G, Ilyin VI, Kyle DJ. Park JH, et al. Among authors: wu g. J Pept Sci. 2012 Jul;18(7):442-8. doi: 10.1002/psc.2407. Epub 2012 May 17. J Pept Sci. 2012. PMID: 22605564

8

Synthesis, in vitro and in vivo biological evaluation, docking studies, and structure--activity relationship (SAR) discussion of dipeptidyl boronic acid proteasome inhibitors composed of beta-amino acids.

Zhu Y, Zhu X, Wu G, Ma Y, Li Y, Zhao X, Yuan Y, Yang J, Yu S, Shao F, Li R, Ke Y, Lu A, Liu Z, Zhang L. Zhu Y, et al. Among authors: wu g. J Med Chem. 2010 Mar 11;53(5):1990-9. doi: 10.1021/jm901407s. J Med Chem. 2010. PMID: 20158184

9

Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors.

Xin M, Zhao X, Huang W, Jin Q, Wu G, Wang Y, Tang F, Xiang H. Xin M, et al. Among authors: wu g. Bioorg Med Chem. 2015 Oct 1;23(19):6250-7. doi: 10.1016/j.bmc.2015.08.039. Epub 2015 Aug 28. Bioorg Med Chem. 2015. PMID: 26344595

10

Synthesis, in vitro and in vivo biological evaluation, and comprehensive understanding of structure-activity relationships of dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids.

Zhu Y, Wu G, Zhu X, Ma Y, Zhao X, Li Y, Yuan Y, Yang J, Yu S, Shao F, Lei M. Zhu Y, et al. Among authors: wu g. J Med Chem. 2010 Dec 23;53(24):8619-26. doi: 10.1021/jm1009742. Epub 2010 Nov 15. J Med Chem. 2010. PMID: 21077681

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